A Novel Microwave Sensor to Detect Specific Biomarkers in Human Cerebrospinal Fluid and Their Relationship to Cellular Ischemia During Thoracoabdominal Aortic Aneurysm Repair

被引:21
|
作者
Fok, M. [1 ,2 ]
Bashir, M. [1 ]
Fraser, H. [1 ]
Strouther, N. [1 ]
Mason, A. [1 ]
机构
[1] Liverpool Heart & Chest Hosp, Thorac Aort Aneurysm Serv, Liverpool L14 3PE, Merseyside, England
[2] Liverpool John Moores Univ, Built Environm & Sustainable Technol BEST Res Ins, RF & Microwave Res Grp, Liverpool L3 2ET, Merseyside, England
关键词
Thoraco-abdominal aneurysms; Electromagnetic wave sensors; Interdigitatedelectrode; In-situ monitoring; NSE SERUM MEASUREMENTS; EVOKED-POTENTIALS; SERIAL S100B; SURGERY; COMPLICATIONS; PARAPLEGIA; MANAGEMENT; DRAINAGE; LACTATE;
D O I
10.1007/s10916-015-0208-4
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Thoraco-abdominal aneurysms (TAAA) represents a particularly lethal vascular disease that without surgical repair carries a dismal prognosis. However, there is an inherent risk from surgical repair of spinal cord ischaemia that can result in paraplegia. One method of reducing this risk is cerebrospinal fluid (CSF) drainage. We believe that the CSF contains clinically significant biomarkers that can indicate impending spinal cord ischaemia. This work therefore presents a novel measurement method for proteins, namely albumin, as a precursor to further work in this area. The work uses an interdigitated electrode (IDE) sensor and shows that it is capable of detecting various concentrations of albumin (from 0 to 100 g/L) with a high degree of repeatability at 200 MHz (R-2=0.991) and 4 GHz (R-2=0.975).
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页数:5
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