Comparative Physicochemical Analysis among 1,4-Butanediol Diglycidyl Ether Cross-Linked Hyaluronic Acid Dermal Fillers

被引：17

作者：

Zerbinati, Nicola ^{[1
]}

Sommatis, Sabrina ^{[2
]}

Maccario, Cristina ^{[2
]}

Capillo, Maria Chiara ^{[2
]}

Grimaldi, Giulia ^{[2
]}

Alonci, Giuseppe ^{[3
]}

Rauso, Raffaele ^{[4
]}

Guida, Stefania ^{[5
]}

Mocchi, Roberto ^{[2
]}

机构：

[1] Univ Insubria, Dept Med & Surg, I-21100 Varese, Italy

[2] Univ Pavia, UB CARE Srl Spin Off, I-27100 Pavia, Italy

[3] Matex Lab Switzerland SA, Dept Res & Dev, CH-1228 Geneva, Switzerland

[4] Univ Campania Luigi Vanvitelli, Maxillofacial Surg Unit, I-81100 Caserta, Italy

[5] Univ Modena & Reggio Emilia, Dermatol Unit, Dept Surg Med Dent & Morphol Sci Related Transpla, I-41124 Modena, Italy

来源：

GELS | 2021年 / 7卷 / 03期

关键词：

hyaluronic acid; rheology; matrix structure; BDDE; injectable HA dermal fillers; aesthetic application; polymers cross-linking technology;

D O I：

10.3390/gels7030139

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

(1) Background: Injectable hyaluronic acid (HA) dermal fillers are used in several chirurgical practices and in aesthetic medicine. HA filler stability can be enhanced through different cross-linking technologies; one of the most frequently cross-linker used is 1,4-butanediol diglycidyl ether (BDDE), also present in the HA-BDDE dermal filler family of the company Matex Lab S.p.A. (Brindisi, Italy). Our overview is focused on their characterization, drawing a correlation between matrix structure, rheological and physicochemical properties related to their cross-linking technologies. (2) Methods: Four different injectable HA hydrogels were characterized through optical microscopic examination and rheological behavior investigation. (3) Results: The cross-linked HA dermal fillers showed a fibrous "spiderweb-like" matrix structure and an elastic and solid-like profile. (4) Conclusions: The comparative analysis represents a preliminary characterization of these injectable medical devices in order to identify their best field of application.

引用

页数：12

共 22 条

[1] Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression [J].

Ashrafizadeh, Milad ;

Mirzaei, Sepideh ;

Gholami, Mohammad Hossein ;

Hashemi, Farid ;

Zabolian, Amirhossein ;

Raei, Mehdi ;

Hushmandi, Kiavash ;

Zarrabi, Ali ;

Voelcker, Nicolas H. ;

Aref, Amir Reza ;

Hamblin, Michael R. ;

Varma, Rajender S. ;

Samarghandian, Saeed ;

Arostegi, I. J. ;

Alzola, M. ;

Kumar, Alan Prem ;

Thakur, Vijay Kumar ;

Nabavi, Noushin ;

Makvandi, Pooyan ;

Tay, Franklin R. ;

Orive, Gorka .

CARBOHYDRATE POLYMERS, 2021, 272

[2] Chemistry, Structures, and Advanced Applications of Nanocomposites from Biorenewable Resources [J].

Ates, Burhan ;

Koytepe, Suleyman ;

Ulu, Ahmet ;

Gurses, Canbolat ;

Thakur, Vijay Kumar .

CHEMICAL REVIEWS, 2020, 120 (17) :9304-9362

[3]

Baby D.K., 2020, Rheology of Polymer Blends and Nanocomposites, P193, DOI [DOI 10.1016/B978-0-12-816957-5.00009-4, 10.1016/B978-0-12-816957-5.00009-4]

[4] A Review of the Metabolism of 1,4-Butanediol Diglycidyl Ether-Crosslinked Hyaluronic Acid Dermal Fillers [J].