Olanzapine pharmacokinetics are similar in Chinese and Caucasian subjects

Aim To compare the pharmacokinetic profiles and dose proportionality of olanzapine in Chinese and Caucasian subjects. Methods Randomized, three-period study with 12 Chinese and 12 Caucasian, healthy, male subjects administered 2.5, 5 and 10 mg olanzapine. Non compartmental pharmacokinetic parameters were derived. Results No statistically significant racial differences in the weight-normalized pharmacokinetic parameters were observed except for V-z/F-norm, or which was 17% lower at the 5- and 10-mg dose in the Chinese group (95% confidence interval 8.49, 10.1 and 8.05, 9.73, respectively), compared with the Caucasian group (9.53, 12.8 and 9.39, 12.0, respectively). Olanzapine's pharmacokinetics were linear and dose proportional in both racial groups. Conclusion The pharmacokinetics of olanzapine are similar in both Chinese and Caucasian racial groups.