Impairment of the Ubiquitin-Proteasome Pathway in RPE Alters the Expression of Inflammation Related Genes

被引：21

作者：

Liu, Zhenzhen ^{[1
]}

Qin, Tingyu ^{[1
]}

Zhou, Jilin ^{[2
]}

Taylor, Allen ^{[1
]}

Sparrow, Janet R. ^{[2
]}

Shang, Fu ^{[1
]}

机构：

[1] Tufts Univ, Lab Nutr & Vis Res, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA

[2] Columbia Univ, Dept Ophthalmol, New York, NY 10027 USA

来源：

RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY | 2014年 / 801卷

关键词：

Age-related macular degeneration; Inflammation; Ubiquitin; Proteasome; Retinal pigment epithelial cells; IL-6; IL-8; MCP-1; Complement factor H; PIGMENT EPITHELIAL-CELLS; FACTOR-H POLYMORPHISM; NF-KAPPA-B; C-REACTIVE PROTEIN; MACULAR DEGENERATION; OXIDATIVE STRESS; CONJUGATING ENZYMES; PARKINSONS-DISEASE; ENDOTHELIAL-CELLS; PATHOGENESIS;

D O I：

10.1007/978-1-4614-3209-8_31

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The ubiquitin-proteasome pathway (UPP) plays an important role in regulating gene expression. Retinal pigment epithelial cells (RPE) are a major source of ocular inflammatory cytokines. In this work we determined the relationship between impairment of the UPP and expression of inflammation-related factors. The UPP could be impaired by oxidative stress or chemical inhibition. Impairment of the UPP in RPE increased the expression of several inflammatory cytokines, such as IL-6 and IL-8. However, the expression of monocyte chemoattractant protein-1 (MCP-1) and complement factor H (CFH) and was reduced upon impairment of the UPP. These data suggest that impairment of the UPP in RPE may be one of the causes of retinal inflammation and abnormal functions of monocyte and the complement system during the pathogenesis of age-related macular degeneration.

引用

页码：237 / 250

页数：14

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