Copper-Promoted Direct Decarboxylative C3-Acylation of Electron-Rich Indolizines Using α-Keto Acids

被引：1

作者：

Liu, Hao ^{[1
]}

Ren, Shaohong ^{[1
]}

Ma, Chuanjun ^{[1
]}

Shi, Guowei ^{[1
]}

Li, Yongchao ^{[1
]}

Duan, Guiyun ^{[1
]}

Ge, Yanqing ^{[1
]}

机构：

[1] Shandong First Med Univ & Shandong Acad Med Sci, Dept Chem & Pharmaceut Engn, 619 Changcheng Rd, Tai An 271016, Shandong, Peoples R China

来源：

CHEMISTRYSELECT | 2022年 / 7卷 / 21期

关键词：

Acylation; C-H activation; Decarboxylation; Indolizine; alpha-Keto acids; RATIOMETRIC FLUORESCENT-PROBE; ORTHO-ACYLATION; OXOCARBOXYLIC ACIDS; SO2; DERIVATIVES; FRET SYSTEM; ARYLATION; INDOLES; CATALYSIS; CU2+; HG2+;

D O I：

10.1002/slct.202104426

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

C-3 substituted indolizines are important biological heterocycles and luminescent molecules. The development of new methods for direct arylation of indolizines is highly desired. Herein, the C3-acylation of electron-rich indolizines with alpha-keto acids through Cu-promoted decarboxylation was descried. Under this simple reaction conditions, a variety of indolizine derivatives were synthesized and characterized. The structure of product 3 a was confirmed in an X-ray crystal analysis. In addition, the mechanism was also proposed.

引用

页数：5

共 8 条

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