The human gut resistome: Current concepts & future prospects

被引：30

作者：

Singh, Shreya ^{[1
]}

Verma, Nipun ^{[2
]}

Taneja, Neelam ^{[1
]}

机构：

[1] Postgrad Inst Med Educ & Res, Dept Med Microbiol, 2nd Floor,Res Block A,Sect 12, Chandigarh 160012, India

[2] Postgrad Inst Med Educ & Res, Dept Hepatol, Chandigarh, India

来源：

INDIAN JOURNAL OF MEDICAL RESEARCH | 2019年 / 150卷 / 04期

关键词：

AMR genes; antimicrobials; bacterial flora; gut; human; enteric pathogens; microbiome; resistome; ANTIBIOTIC-RESISTANCE GENES; FECAL MICROBIOTA TRANSPLANTATION; ESCHERICHIA-COLI; NETWORK; RESERVOIR; TRACT; DNA; CONSUMPTION; EVOLUTION; INSIGHTS;

D O I：

10.4103/ijmr.IJMR_1979_17

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The human gut is home to a myriad of organisms. While some are harmless commensals, others are transient, pathogenic flora. The gut microbiome is composed of diverse bacterial flora, and apart from playing a major role in protecting from various infectious and non-infectious diseases, it plays an important role in resistance to antimicrobials. The collection of genes or genetic material that confers antimicrobial resistance constitutes the gut resistome, and it may involve the pathogens or commensals of the intestinal tract. The diversity of this gut resistome is influenced by various environmental factors including the diet and antibiotic exposure. This review highlights the recent concepts pertaining to the human gut resistome, factors affecting it, how it impacts human health and diseases, methods to study the resistome and potential therapeutic approaches.

引用

页码：345 / 358

页数：14

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