Synthesis and Evaluation of a Star Amphiphilic Block Copolymer from Poly(E-caprolactone) and Poly(ethylene oxide) as Load and Release Carriers for Guest Molecules

被引：10

作者：

Jiang, Guohua ^{[1
,2
]}

Xu, Hao ^{[1
,2
]}

机构：

[1] Zhejiang Sci Tech Univ, Minist Educ, Key Lab Adv Text Mat & Mfg Technol ATMT, Hangzhou 310018, Peoples R China

[2] Zhejiang Sci Tech Univ, Coll Mat & Text, Dept Mat Engn, Hangzhou 310018, Peoples R China

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2010年 / 118卷 / 03期

基金：

中国国家自然科学基金;

关键词：

ring-opening polymerization; star polymers; drug delivery systems; CROSS-LINKING MACROMONOMERS; DRUG-DELIVERY SYSTEMS; DIBLOCK COPOLYMER; AQUEOUS-SOLUTIONS; POLYMERS; CORE; MICELLES; ATRP; CRYSTALLIZATION; POLYMERIZATION;

D O I：

10.1002/app.32364

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The use of polymeric materials as the carrier in the controlled release of guest molecules has become an important research area in the polymeric materials science, because of their advantages of the safety, efficacy and patient convenience. One of them, star amphiphilic polymer can self-assemble into supermolecular structure (polymer micelles) by the balance of hydrophilic and hydrophobic interaction. In this study, star amphiphilic copolymer consisting of hydrophobic and biodegradable poly(E-caprolactone) (PCL) and hydrophilic poly(ethylene oxide) (PEO) blocks were synthesized by two-step ring-opening polymerization. The resultant polymer was characterizated by FTIR, H-1-NMR, and DSC to determine its chemical structure. The morpholoy of the polymer micelles was analyzed by TEM. Using star-PCL-b-PEO as carriers and congo red as model guest molecules, the encapsulation and release properties were investigated by UV-visable analysis. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 118: 1372-1379, 2010

引用

页码：1372 / 1379

页数：8

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