Silver-catalyzed decarboxylative cyclization for the synthesis of substituted pyrazoles from 1,2-diaza-1,3-dienes and α-keto acids

被引：17

作者：

Katiyar, Sarita ^{[1
,2
]}

Kumar, Abhishek ^{[1
]}

Sashidhara, Koneni, V ^{[1
,2
,3
]}

机构：

[1] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Sect 10,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India

[2] CSIR Human Resource Dev Ctr, Acad Sci & Innovat Res, CSIR HRDC Campus,Sect 19, Ghaziabad 201002, Uttar Pradesh, India

[3] CSIR Cent Drug Res Inst, Sophisticated Analyt Instrument Facil & Res, Sect 10,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 52期

关键词：

SITU GENERATED 1,2-DIAZA-1,3-DIENES; EFFICIENT; ACCESS; FUNCTIONALIZATION; CYCLOADDITION; SELECTIVITY; HYDRAZONES; ESTERS;

D O I：

10.1039/d2cc01793h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A silver-catalyzed decarboxylative cyclization process has been developed for the synthesis of substituted pyrazoles from the readily available 1,2-diaza-1,3-dienes and alpha-keto acids. Under the optimized conditions, a series of multisubstituted pyrazoles were well prepared in moderate to good yields. In addition, the synthetic utility of this protocol has been demonstrated by synthesizing analogs of FDA approved drugs such as anti-inflammatory drug, lonazolac and antiobesity drug, rimonabant.

引用

页码：7297 / 7300

页数：4

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