Sex-Related Differences in Locomotion and Climbing of C57Bl/6NTac Mice in a Novel Environment

被引：20
作者：
Borbelyova, V [1 ]
Janisova, K. [2 ]
Myslivecek, J. [2 ]
Riljak, V [2 ]
机构：
[1] Comenius Univ, Inst Mol Biomed, Fac Med, Bratislava, Slovakia
[2] Charles Univ Prague, Dept Physiol, Fac Med 1, Prague, Czech Republic
来源：
PHYSIOLOGICAL RESEARCH | 2019年 / 68卷
关键词：
Automatic behavior registration; Gender differences; Grid-climbing activity; Mouse; ANXIETY-LIKE BEHAVIOR; OPEN-FIELD TEST; DOMOIC ACID; VALIDATION; LABORAS(TM); SYSTEM; MOUSE; LIGHT;
D O I：
10.33549/physiolres.934348
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Laboratory mice in standard laboratory cages, besides horizontal and vertical locomotor activity, spontaneously display cage-bar related activities such as cage-grid climbing. Although, gridclimbing activity is one of the major components of spontaneous home-cage behavior of mice, its exact role is not fully understood. This study aimed to describe the sex-differences in coping with novelty and in spontaneous behavior of laboratory mice concerning the cage-climbing activity in an observer-independent open field test. Adult mice of both sexes (C57Bl/6NTac) underwent behavioral testing in LABORAS system. Female mice travelled significantly longer distance (by 30 %, p<0.05) and showed higher grid-climbing activity (by 50 %, p<0.05) than males. Based on our results, the grid-climbing is a sex-dependent activity of mice, however, its exact role remains to be elucidated.
引用
收藏
页码：S353 / S359
页数：7
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