Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes

被引：40
作者：
Lee, Dong-Gi [1 ]
Jang, Ik Soon [1 ,2 ]
Yang, Kyeong Eun [1 ]
Yoon, So-Jung [1 ]
Baek, Sujeong [3 ]
Lee, Joo Yong [3 ]
Suzuki, Tatsuro [4 ]
Chung, Keun-Yook [5 ]
Woo, Sun-Hee [6 ]
Choi, Jong-Soon [1 ,3 ]
机构：
[1] Korea Basic Sci Inst, Biol Disaster Anal Grp, Daejeon 34133, South Korea
[2] Korea Basic Sci Inst, Drug & Dis Target Grp, Daejeon 34133, South Korea
[3] Chungnam Natl Univ, Grad Sch Analyt Sci & Technol, Daejeon 34134, South Korea
[4] Natl Agr Res Ctr Hokkaido Reg, Memuro, Hokkaido 0820081, Japan
[5] Chungbuk Natl Univ, Dept Agr Chem, Cheongju 28644, South Korea
[6] Chungbuk Natl Univ, Dept Crop Sci, Cheongju 28644, South Korea
来源：
ACTA PHARMACEUTICA | 2016年 / 66卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
tartary buckwheat sprout; rutin; type; 2; diabetes; insulin signaling; ANTIOXIDANT ACTIVITY; GAERTN;
D O I：
10.1515/acph-2016-0021
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This study investigates the anti-diabetic effects of rutin from tartary buckwheat sprout in type 2 diabetes mouse model. The rutin content in tartary buckwheat sprout (TBS) is five times higher than that found in common buckwheat sprout (CBS) as evident from high-performance liquid chromatography analysis. Administration of either rutin or TBS ethanolic extract to diabetes mice decreased the serum glucose level significantly. Rutin down-regulated the expression levels of protein-tyrosine phosphatase 1B; it is negative regulator of insulin pathway, both transcriptionally and translationally in myocyte C2C12 in a dose-dependent manner. In conclusion, rutin can play a critical role in down-regulation of serum glucose level in type 2 diabetes.
引用
收藏
页码：297 / 302
页数：6
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