Protein/peptide secondary structural mimics: design, characterization, and modulation of protein-protein interactions

被引：19
|
作者：
Wang, Zhipeng A. [1 ,3 ]
Ding, Xiaozhe Z. [2 ,4 ]
Tian, Chang-Lin [1 ]
Zheng, Ji-Shen [1 ]
机构：
[1] Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China
[2] Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
[3] Texas A&M Univ, Dept Chem, College Stn, TX 77840 USA
[4] CALTECH, Dept Bioengn, Pasadena, CA 91125 USA
来源：
RSC ADVANCES | 2016年 / 6卷 / 66期
基金：
中国国家自然科学基金;
关键词：
SOLID-PHASE SYNTHESIS; ALPHA-HELIX MIMETICS; AZACYCLOALKANE AMINO-ACIDS; HIGH-HANGING FRUIT; CHEMICAL-SYNTHESIS; CONFORMATIONAL-ANALYSIS; BETA-PEPTIDES; PEPTOID OLIGOMERS; CRYSTAL-STRUCTURE; TURN STRUCTURE;
D O I：
10.1039/c6ra13976k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Protein-protein interactions (PPIs) play a critical role in many essential biological processes, and numerous diseases result from malfunctioning PPIs. The modulation of undesirable PPIs via synthetic chemical molecules has long been considered of medical importance, but still remains challenging. Thanks to the development of synthetic chemistry, chemists can synthesize protein/peptide secondary structure mimics to modulate the specific PPIs. This review discusses general aspects of novel artificial peptide secondary structure mimics for the modulation of PPIs, their therapeutic applications and future prospects.
引用
收藏
页码：61599 / 61609
页数：11
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