Cognitive dysfunction in patients with type 2 diabetes

被引：215

作者：

Reijmer, Yael D. ^{[1
]}

van den Berg, Esther ^{[1
,2
]}

Ruis, Carla ^{[1
,2
]}

Kappelle, L. Jaap ^{[1
]}

Biessels, Geert Jan ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Neurol, Rudolf Magnus Inst Neurosci, NL-3508 GA Utrecht, Netherlands

[2] Univ Utrecht, Dept Expt Psychol, Utrecht, Netherlands

来源：

DIABETES-METABOLISM RESEARCH AND REVIEWS | 2010年 / 26卷 / 07期

关键词：

diabetes mellitus; cognitive functioning; dementia; vascular risk factors; imaging; neuropsychological assessment; IMPROVED GLYCEMIC CONTROL; INSULIN-DEGRADING ENZYME; VASCULAR RISK-FACTORS; WHITE-MATTER HYPERINTENSITIES; IMPAIRED GLUCOSE-TOLERANCE; 3RD NATIONAL-HEALTH; ALZHEIMERS-DISEASE; APOLIPOPROTEIN-E; BLOOD-PRESSURE; OLDER PATIENTS;

D O I：

10.1002/dmrr.1112

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

People with diabetes mellitus are at increased risk of cognitive dysfunction and dementia. This review explores the nature and severity of cognitive changes in patients with type 2 diabetes. Possible risk factors such as hypo- and hyperglycemia, vascular risk factors, micro- and macrovascular complications, depression and genetic factors will be examined, as well as findings from brain imaging and autopsy studies. We will show that type 2 diabetes is associated with modest cognitive decrements in non-demented patients that evolve only slowly over time, but also with an increased risk of more severe cognitive deficits and dementia. There is a dissociation between these two 'types' of cognitive dysfunction with regard to affected age groups and course of development. Therefore, we hypothesize that the mild and severe cognitive deficits observed in patients with type 2 diabetes reflect separate processes, possibly with different risk factors and aetiologies. Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：507 / 519

页数：13

共 167 条

[1] Postprandial plasma glucose excursions and cognitive functioning in aged type 2 diabetics [J].