Exploration of disease mechanism in acute kidney injury using a multiplex bead array assay: a nested case-control pilot study

被引：7

作者：

Liangos, Orfeas ^{[1
,2
]}

Addabbo, Francesco ^{[3
]}

Tighiouart, Hocine ^{[4
]}

Goligorsky, Michael ^{[5
]}

Jaber, Bertrand L. ^{[2
]}

机构：

[1] Klinikum Coburg, Med Klin 3, Div Nephrol, D-96450 Coburg, Germany

[2] Tufts Univ, Sch Med, St Elizabeths Med Ctr, Kidney & Dialysis Res Lab, Boston, MA 02111 USA

[3] Univ Bari, Dept Pharmacol & Human Physiol, Fac Med & Surg, I-70121 Bari, Italy

[4] Tufts Med Ctr, Biostat Res Ctr, Boston, MA USA

[5] New York Med Coll, Div Nephrol, Valhalla, NY 10595 USA

来源：

BIOMARKERS | 2010年 / 15卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Cardiac surgery; cardiopulmonary bypass; acute renal failure; pathophysiology; biomarker; ACUTE-RENAL-FAILURE; SYSTEMIC INFLAMMATORY RESPONSE; CARDIAC-SURGERY; CARDIOPULMONARY BYPASS; PROSPECTIVE COHORT; SERUM CREATININE; XMAP TECHNOLOGY; FRACTALKINE; CLASSIFICATION; DYSFUNCTION;

D O I：

10.3109/1354750X.2010.485252

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background: Acute kidney injury (AKI) following cardiac surgery with cardiopulmonary bypass (CPB) causes increased morbidity and mortality. Objective: To evaluate the plasma profile of biomarkers potentially involved in AKI development following CPB. Methods: In a nested case-control study, plasma levels of 27 biomarkers in 11 AKI cases were compared with 25 controls. Results: Pre-CPB, plasma levels of epidermal growth factor and macrophage inflammatory protein-1 beta, 2 h following CPB, soluble vascular cell adhesion molecule-1 (sVCAM-1), fractalkine and macrophage inflammatory protein-1 alpha, and at later time points, sVCAM-1 and interleukin-6 were associated with AKI. Conclusion: Biomarkers associated with AKI following CPB may merit further study.

引用

页码：436 / 445

页数：10

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