Exploration of disease mechanism in acute kidney injury using a multiplex bead array assay: a nested case-control pilot study

被引：7
作者：
Liangos, Orfeas [1 ,2 ]
Addabbo, Francesco [3 ]
Tighiouart, Hocine [4 ]
Goligorsky, Michael [5 ]
Jaber, Bertrand L. [2 ]
机构：
[1] Klinikum Coburg, Med Klin 3, Div Nephrol, D-96450 Coburg, Germany
[2] Tufts Univ, Sch Med, St Elizabeths Med Ctr, Kidney & Dialysis Res Lab, Boston, MA 02111 USA
[3] Univ Bari, Dept Pharmacol & Human Physiol, Fac Med & Surg, I-70121 Bari, Italy
[4] Tufts Med Ctr, Biostat Res Ctr, Boston, MA USA
[5] New York Med Coll, Div Nephrol, Valhalla, NY 10595 USA
来源：
BIOMARKERS | 2010年 / 15卷 / 05期
基金：
美国国家卫生研究院;
关键词：
Cardiac surgery; cardiopulmonary bypass; acute renal failure; pathophysiology; biomarker; ACUTE-RENAL-FAILURE; SYSTEMIC INFLAMMATORY RESPONSE; CARDIAC-SURGERY; CARDIOPULMONARY BYPASS; PROSPECTIVE COHORT; SERUM CREATININE; XMAP TECHNOLOGY; FRACTALKINE; CLASSIFICATION; DYSFUNCTION;
D O I：
10.3109/1354750X.2010.485252
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: Acute kidney injury (AKI) following cardiac surgery with cardiopulmonary bypass (CPB) causes increased morbidity and mortality. Objective: To evaluate the plasma profile of biomarkers potentially involved in AKI development following CPB. Methods: In a nested case-control study, plasma levels of 27 biomarkers in 11 AKI cases were compared with 25 controls. Results: Pre-CPB, plasma levels of epidermal growth factor and macrophage inflammatory protein-1 beta, 2 h following CPB, soluble vascular cell adhesion molecule-1 (sVCAM-1), fractalkine and macrophage inflammatory protein-1 alpha, and at later time points, sVCAM-1 and interleukin-6 were associated with AKI. Conclusion: Biomarkers associated with AKI following CPB may merit further study.
引用
收藏
页码：436 / 445
页数：10
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