HEXIM1 induction exerts a mechanistic role and is a biomarker of lethal activity of BRD4 antagonist against human AML cells

被引：1
|
作者：
Devaraj, Santhana G. T. [1 ]
Fiskus, Warren [1 ]
Sharma, Sunil [2 ]
Qi, Jun [3 ]
Shah, Bhavin [1 ]
Schaub, Leasha J. [1 ]
Rodriguez, Melissa [1 ]
Liu, Ka [1 ]
Iyer, Swaminathan P. [1 ]
Bradner, James E. [3 ]
Bhalla, Kapil N. [1 ]
机构：
[1] Houston Methodist Res Inst, Houston, TX USA
[2] Huntsman Canc Inst, Salt Lake City, UT USA
[3] Dana Farber Canc Inst, Boston, MA 02115 USA
来源：
CANCER RESEARCH | 2014年 / 74卷 / 19期
关键词：
D O I：
10.1158/1538-7445.AM2014-3686
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
3686
引用
收藏
页数：1
相关论文
共 18 条
  • [1] Mechanistic Role of HEXIM1 Induction in BRD4-Antagonist Mediated Growth Inhibition, Differentiation and in Vivo Lethal Activity Against Human AML Blast Progenitor Cells
    Devaraj, Santhana G. T.
    Fiskus, Warren
    Shah, Bhavin
    Sharma, Sunil
    Qi, Jun
    Sun, Baohua
    Saha, Saikat
    Iyer, Swaminathan Padmanabhan
    Zu, Youli
    Bradner, James
    Bhalla, Kapil N.
    BLOOD, 2014, 124 (21)
  • [2] HEXIM1 induction is mechanistically involved in mediating anti-AML activity of BET protein bromodomain antagonist
    S G T Devaraj
    W Fiskus
    B Shah
    J Qi
    B Sun
    S P Iyer
    S Sharma
    J E Bradner
    K N Bhalla
    Leukemia, 2016, 30 : 504 - 508
  • [3] HEXIM1 induction is mechanistically involved in mediating anti-AML activity of BET protein bromodomain antagonist
    Devaraj, S. G. T.
    Fiskus, W.
    Shah, B.
    Qi, J.
    Sun, B.
    Iyer, S. P.
    Sharma, S.
    Bradner, J. E.
    Bhalla, K. N.
    LEUKEMIA, 2016, 30 (02) : 504 - 508
  • [4] Ubenimex enhances Brd4 inhibition by suppressing HEXIM1 autophagic degradation and suppressing the Akt pathway in glioma cells
    Han, Liping
    Zhao, Qingwei
    Liang, Xianhong
    Wang, Xiaoqing
    Zhang, Zhen
    Ma, Zhiguo
    Zhao, Miaoqing
    Wang, Aihua
    Liu, Shuai
    ONCOTARGET, 2017, 8 (28) : 45643 - 45655
  • [5] BRD4 antagonist-based therapy exerts lethal activity against FLT3 mutation expressing AML cells resistant to FLT3 tyrosine kinase inhibitors
    Rodriguez, Melissa
    Fiskus, Warren
    Sharma, Sunil
    Qi, Jun
    Schaub, Leasha J.
    Shah, Bhavin
    Devaraj, Santhana G. T.
    Liu, Ka
    Iyer, Swaminathan
    Bradner, James E.
    Bhalla, Kapil N.
    CANCER RESEARCH, 2014, 74 (19)
  • [6] Combined Therapy With BRD4 Antagonist and JAK Inhibitor Is Synergistically Lethal Against Human Myeloproliferative Neoplasm (MPN) Cells
    Valenta, John A.
    Fiskus, Warren
    Manshouri, Taghi
    Sharma, Sunil
    Qi, Jun
    Schaub, Leasha J.
    Shah, Bhavin
    Rodriguez, Melissa
    Devaraj, Santhana
    Iyer, Swaminathan Padmanabhan
    Verstovsek, Srdan
    Bradner, James E.
    Bhalla, Kapil N.
    BLOOD, 2013, 122 (21)
  • [7] Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human AML.
    Bhalla, Kapil N.
    Fiskus, Warren
    Peth, Karissa
    JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (15)
  • [8] BRD4 Antagonist and Histone Deacetylase Inhibitor: A Novel Synergistic Combination Against Human Acute Myeloid Leukemia (AML) Cells
    Fiskus, Warren
    Sharma, Sunil
    Qi, Jun
    Valenta, John A.
    Schaub, Leasha J.
    Shah, Bhavin
    Pethi, Karissa
    Jakkula, Laxmi U. M. R.
    Rodriguez, Melissa
    Devaraj, Santhana
    Iyer, Swaminathan Padmanabhan
    Bradner, James E.
    Bhalla, Kapil N.
    BLOOD, 2013, 122 (21)
  • [9] Lethal activity of BRD4 PROTAC degrader QCA570 against bladder cancer cells
    Wang, Qiang
    Li, Baohu
    Zhang, Wenkai
    Li, Zhuoyue
    Jiang, Bo
    Hou, Sichuan
    Ma, Shumin
    Qin, Chong
    FRONTIERS IN CHEMISTRY, 2023, 11
  • [10] Human T-Lymphotropic Virus Type 1 Tax Protein Complexes with P-TEFb and Competes for Brd4 and 7SK snRNP/HEXIM1 Binding
    Cho, Won-Kyung
    Jang, Moon Kyoo
    Huang, Keven
    Pise-Masison, Cynthia A.
    Brady, John N.
    JOURNAL OF VIROLOGY, 2010, 84 (24) : 12801 - 12809
12