OGEE: an online gene essentiality database

被引：130

作者：

Chen, Wei-Hua ^{[1
]}

Minguez, Pablo ^{[1
]}

Lercher, Martin J. ^{[2
]}

Bork, Peer ^{[1
,3
]}

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

[2] Univ Dusseldorf, Inst Comp Sci, D-40225 Dusseldorf, Germany

[3] Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany

来源：

NUCLEIC ACIDS RESEARCH | 2012年 / 40卷 / D1期

关键词：

TRANSPOSON MUTAGENESIS; CAENORHABDITIS-ELEGANS; FRANCISELLA-NOVICIDA; FUNCTIONAL-ANALYSIS; DUPLICATE GENES; IDENTIFICATION; PRIORITIZATION; ONTOLOGY; SURVIVAL; LIBRARY;

D O I：

10.1093/nar/gkr986

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

OGEE is an Online GEne Essentiality database. Its main purpose is to enhance our understanding of the essentiality of genes. This is achieved by collecting not only experimentally tested essential and non-essential genes, but also associated gene features such as expression profiles, duplication status, conservation across species, evolutionary origins and involvement in embryonic development. We focus on large-scale experiments and complement our data with text-mining results. Genes are organized into data sets according to their sources. Genes with variable essentiality status across data sets are tagged as conditionally essential, highlighting the complex interplay between gene functions and environments. Linked tools allow the user to compare gene essentiality among different gene groups, or compare features of essential genes to non-essential genes, and visualize the results. OGEE is freely available at http://ogeedb.embl.de.

引用

页码：D901 / D906

页数：6

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