Critical Role of O-Linked β-N-Acetylglucosamine Transferase in Prostate Cancer Invasion, Angiogenesis, and Metastasis

被引：246

作者：

Lynch, Thomas P. ^{[1
]}

Ferrer, Christina M. ^{[1
]}

Jackson, S. RaElle ^{[1
]}

Shahriari, Kristina S. ^{[1
]}

Vosseller, Keith ^{[1
]}

Reginato, Mauricio J. ^{[1
]}

机构：

[1] Drexel Univ, Coll Med, Dept Biochem & Mol Biol, Philadelphia, PA 19102 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2012年 / 287卷 / 14期

基金：

美国国家卫生研究院;

关键词：

TRANSCRIPTION FACTOR FOXM1; GENE-EXPRESSION PROFILES; GLCNAC TRANSFERASE; INSULIN-RESISTANCE; NUTRIENT SENSOR; METABOLISM; PROGRESSION; BREAST; GLYCOSYLATION; MECHANISMS;

D O I：

10.1074/jbc.M111.302547

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Cancer cells display altered metabolism and expression of the nutrient sensor O-linked beta-N-acetylglucosamine transferase (OGT). Results: Through regulation of FoxM1, OGT contributes to increased invasion, angiogenesis, and metastasis of prostate cancer cells. Conclusion: OGT plays a critical role in prostate cancer. Significance: OGT may provide a novel therapeutic target for treating prostate cancer.

引用

页码：11070 / 11081

页数：12

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