Conventional QT Variability Measurement vs. Template Matching Techniques: Comparison of Performance Using Simulated and Real ECG

被引:46
作者
Baumert, Mathias [1 ,2 ]
Starc, Vito [3 ]
Porta, Alberto [4 ]
机构
[1] Univ Adelaide, Sch Elect & Elect Engn, Adelaide, SA, Australia
[2] Univ Adelaide, Ctr Heart Rhythm Disorders, Adelaide, SA, Australia
[3] Univ Ljubljana, Sch Med, Ljubljana, Slovenia
[4] Univ Milan, Galeazzi Orthoped Inst, Dept Technol Hlth, Milan, Italy
基金
澳大利亚研究理事会;
关键词
TORSADES-DE-POINTES; VENTRICULAR REPOLARIZATION DURATION; SHORT-TERM VARIABILITY; HEAD-UP TILT; INTERVAL VARIABILITY; SYSTOLIC DYSFUNCTION; SOTALOL; DOGS; ELECTROCARDIOGRAM; CARDIOMYOPATHY;
D O I
10.1371/journal.pone.0041920
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Increased beat-to-beat variability in the QT interval (QTV) of ECG has been associated with increased risk for sudden cardiac death, but its measurement is technically challenging and currently not standardized. The aim of this study was to investigate the performance of commonly used beat-to-beat QT interval measurement algorithms. Three different methods (conventional, template stretching and template time shifting) were subjected to simulated data featuring typical ECG recording issues (broadband noise, baseline wander, amplitude modulation) and real short-term ECG of patients before and after infusion of sotalol, a QT interval prolonging drug. Among the three algorithms, the conventional algorithm was most susceptible to noise whereas the template time shifting algorithm showed superior overall performance on simulated and real ECG. None of the algorithms was able to detect increased beat-to-beat QT interval variability after sotalol infusion despite marked prolongation of the average QT interval. The QTV estimates of all three algorithms were inversely correlated with the amplitude of the T wave. In conclusion, template matching algorithms, in particular the time shifting algorithm, are recommended for beat-to-beat variability measurement of QT interval in body surface ECG. Recording noise, T wave amplitude and the beat-rejection strategy are important factors of QTV measurement and require further investigation.
引用
收藏
页数:8
相关论文
共 29 条
[1]   PHARMACOLOGICAL BASIS OF THE ANTIARRHYTHMIC AND HEMODYNAMIC-EFFECTS OF SOTALOL [J].
ANTONACCIO, MJ ;
GOMOLL, A .
AMERICAN JOURNAL OF CARDIOLOGY, 1993, 72 (04) :A27-A37
[2]   QT interval variability and cardiac norepinephrine spillover in patients with depression and panic disorder [J].
Baumert, Mathias ;
Lambert, Gavin W. ;
Dawood, Tye ;
Lambert, Elisabeth A. ;
Esler, Murray D. ;
McGrane, Mariee ;
Barton, David ;
Nalivaiko, Eugene .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2008, 295 (03) :H962-H968
[3]  
Baumert M, 2008, SLEEP, V31, P959
[4]   Relation between QT interval variability and cardiac sympathetic activity in hypertension [J].
Baumert, Mathias ;
Schlaich, Markus P. ;
Nalivaiko, Eugene ;
Lambert, Elisabeth ;
Sari, Carolina Ika ;
Kaye, David M. ;
Elser, Murray D. ;
Sanders, Prashanthan ;
Lambert, Gavin .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2011, 300 (04) :H1412-H1417
[5]   Beat-to-beat QT interval variability - Novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathy [J].
Berger, RD ;
Kasper, EK ;
Baughman, KL ;
Marban, E ;
Calkins, H ;
Tomaselli, GF .
CIRCULATION, 1997, 96 (05) :1557-1565
[6]   Baseline Values and Sotalol-Induced Changes of Ventricular Repolarization Duration, Heterogeneity, and Instability in Patients With a History of Drug-Induced Torsades de Pointes [J].
Couderc, Jean-Philippe ;
Kaab, Stefan ;
Hinterseer, Martin ;
McNitt, Scott ;
Xia, Xiaojuan ;
Fossa, Anthony ;
Beckmann, Britt M. ;
Polonsky, Slava ;
Zareba, Wojciech .
JOURNAL OF CLINICAL PHARMACOLOGY, 2009, 49 (01) :6-16
[7]   Gender differences and risk of ventricular tachycardia or ventricular fibrillation [J].
Haigney, Mark C. ;
Zareba, Wojciech ;
Nasir, Javed M. ;
McNitt, Scott ;
McAdams, Dougas ;
Gentesk, Philip J. ;
Goldstein, Robert E. ;
Moss, Arthur J. .
HEART RHYTHM, 2009, 6 (02) :180-186
[8]   QT interval variability and spontaneous ventricular tachycardia or fibrillation in the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II patients [J].
Haigney, MC ;
Zareba, W ;
Gentlesk, PJ ;
Goldstein, RE ;
Illovsky, M ;
McNitt, S ;
Andrews, ML ;
Moss, AJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 44 (07) :1481-1487
[9]   Relation between Beat-to-Beat QT Interval Variability and T-Wave Amplitude in Healthy Subjects [J].
Hasan, Muhammad A. ;
Abbott, Derek ;
Baumert, Mathias .
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY, 2012, 17 (03) :195-203
[10]   Usefulness of Short-Term Variability of QT Intervals as a Predictor for Electrical Remodeling and Proarrhythmia in Patients With Nonischemic Heart Failure [J].
Hinterseer, Martin ;
Beckmann, Britt-Maria ;
Thomsen, Morten B. ;
Pfeufer, Arne ;
Ulbrich, Michael ;
Sinner, Moritz F. ;
Perz, Siegfried ;
Wichmann, H. -Erich ;
Lengyel, Csaba ;
Schimpf, Rainer ;
Maier, Sebastian K. G. ;
Andras Varro ;
Vos, Marc A. ;
Steinbeck, Gerhard ;
Kaeaeb, Stefan .
AMERICAN JOURNAL OF CARDIOLOGY, 2010, 106 (02) :216-220