Regulation of neutrophil trafficking from the bone marrow

被引：65

作者：

Day, Ryan B. ^{[1
]}

Link, Daniel C. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Internal Med, Div Oncol, St Louis, MO 63110 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2012年 / 69卷 / 09期

关键词：

Neutrophils; Granulocyte colony-stimulating factor (G-CSF); CXCR4; CXCR2; CXCL12 (stromal derived factor-1; SDF-1); CXCL1; CXCL2; Leukocyte trafficking; WHIM syndrome; COLONY-STIMULATING FACTOR; HEMATOPOIETIC PROGENITOR CELLS; CHEMOKINE RECEPTOR CXCR4; TERMINUS-TRUNCATED CXCR4; WHIM-SYNDROME; DEFICIENT MICE; IN-VIVO; G-CSF; RAPID MOBILIZATION; STEM-CELLS;

D O I：

10.1007/s00018-011-0870-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neutrophils are an essential component of the innate immune response and a major contributor to inflammation. Consequently, neutrophil homeostasis in the blood is highly regulated. Neutrophil number in the blood is determined by the balance between neutrophil production in the bone marrow and release from the bone marrow to blood with neutrophil clearance from the circulation. This review will focus on mechanisms regulating neutrophil release from the bone marrow. In particular, recent data demonstrating a central role for the chemokines CXCL12 and CXCL2 in regulating neutrophil egress from the bone marrow will be discussed.

引用

页码：1415 / 1423

页数：9

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