How to improve long-term outcome after liver transplantation?

被引：53

作者：

Durand, Francois ^{[1
]}

机构：

[1] Univ Paris Diderot, Hosp Beaujon, INSERM, Hepatol & Liver Intens Care, Clichy, France

来源：

LIVER INTERNATIONAL | 2018年 / 38卷

关键词：

de novo malignancy; immunosuppression; liver transplantation; metabolic syndrome; viral hepatitis; PRIMARY SCLEROSING CHOLANGITIS; RISK-FACTORS; NONALCOHOLIC STEATOHEPATITIS; HEPATITIS-B; RECIPIENTS; DISEASE; IMPACT; RECURRENCE; REJECTION; SURVIVAL;

D O I：

10.1111/liv.13651

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The outcome of liver transplantation has markedly improved in the last 3 decades. Although early post-transplantation outcomes have improved over time, this is not true of the long-term outcome. The majority of late deaths are not related to graft dysfunction, and with the advent of new antiviral agents, recurrence of hepatitis B and hepatitis C after transplantation may no longer represent a source of graft loss and patient's death in the long term. The complications of metabolic syndrome may represent an increasing source of morbidity and mortality after transplantation. This study discusses these modifiable factors associated with late mortality to improve the long-term results of transplantation.

引用

页码：134 / 138

页数：5

共 38 条

[1] Lower Malignancy Rates in Renal Allograft Recipients Converted to Sirolimus-Based, Calcineurin Inhibitor-Free Immunotherapy: 24-Month Results From the CONVERT Trial [J].

Alberu, Josefina ;

Pascoe, Michael D. ;

Campistol, Josep M. ;

Schena, Francesco P. ;

del Carmen Rial, Maria ;

Polinsky, Martin ;

Neylan, John F. ;

Korth-Bradley, Joan ;

Goldberg-Alberts, Robert ;

Maller, Eric S. .

TRANSPLANTATION, 2011, 92 (03) :303-310

[2] ELITA consensus statements on the use of DAAs in liver transplant candidates and recipients [J].

Belli, Luca S. ;

Duvoux, Christophe ;

Berenguer, Marina ;

Berg, Thomas ;

Coilly, Audrey ;

Colle, Isabelle ;

Fagiuoli, Stefano ;

Khoo, Saye ;

Pageaux, Georges Philippe ;

Puoti, Massimo ;

Samuel, Didier ;

Strazzabosco, Mario .

JOURNAL OF HEPATOLOGY, 2017, 67 (03) :585-602

[3] Reduced-Dose Tacrolimus with Mycophenolate Mofetil vs. Standard-Dose Tacrolimus in Liver Transplantation: A Randomized Study [J].

Boudjema, K. ;

Camus, C. ;

Saliba, F. ;

Calmus, Y. ;

Salame, E. ;

Pageaux, G. ;

Ducerf, C. ;

Duvoux, C. ;

Mouchel, C. ;

Renault, A. ;

Compagnon, P. ;

Lorho, R. ;

Bellissant, E. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2011, 11 (05) :965-976

[4] Sirolimus therapy after early cyclosporine withdrawal reduces the risk for cancer in adult renal transplantation [J].

Campistol, Josep M. ;

Eris, Josette ;

Oberbauer, Rainer ;

Friend, Peter ;

Hutchison, Brian ;

Morales, Jose M. ;

Claesson, Kerstin ;

Stallone, Giovanni ;

Russ, Graeme ;

Rostaing, Lionel ;

Kreis, Henri ;

Burke, James T. ;

Brault, Yves ;

Scarola, Joseph A. ;

Neylan, John F. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (02) :581-589

[5] Roadmap for Improving Patient and Graft Survival in the Next 10 Years [J].

Charlton, Michael R. .

LIVER TRANSPLANTATION, 2016, 22 :S71-S78

[6]

de Fijter JW, 2017, TRANSPLANTATION, V101, P45, DOI 10.1097/TP.0000000000001447

[7] Non-Alcoholic Fatty Liver Disease in Liver Transplant Recipients: Another Story of "Seed and Soil" [J].

Dumortier, Jerome ;

Giostra, Emiliano ;

Belbouab, Soraya ;

Morard, Isabelle ;

Guillaud, Olivier ;

Spahr, Laurent ;

Boillot, Olivier ;

Rubbia-Brandt, Laura ;

Scoazec, Jean-Yves ;

Hadengue, Antoine .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2010, 105 (03) :613-620

[8] Pathogenesis of Hepatorenal Syndrome: Implications for Therapy [J].

Durand, Francois ;

Graupera, Isabel ;

Gines, Pere ;

Olson, Jody C. ;

Nadim, Mitra K. .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2016, 67 (02) :318-328

[9] Spectrum of Cancer Risk Among US Solid Organ Transplant Recipients [J].

Engels, Eric A. ;

Pfeiffer, Ruth M. ;

Fraumeni, Joseph F., Jr. ;

Kasiske, Bertram L. ;

Israni, Ajay K. ;

Snyder, Jon J. ;

Wolfe, Robert A. ;

Goodrich, Nathan P. ;

Bayakly, A. Rana ;

Clarke, Christina A. ;

Copeland, Glenn ;

Finch, Jack L. ;

Fleissner, Mary Lou ;

Goodman, Marc T. ;

Kahn, Amy ;

Koch, Lori ;

Lynch, Charles F. ;

Madeleine, Margaret M. ;

Pawlish, Karen ;

Rao, Chandrika ;

Williams, Melanie A. ;

Castenson, David ;

Curry, Michael ;

Parsons, Ruth ;

Fant, Gregory ;

Lin, Monica .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 306 (17) :1891-1901

[10] Risk factors for renal dysfunction in the postoperative course of liver transplant [J].

Gallardo, ML ;

Gutierrez, MEH ;

Pérez, GS ;

Balsera, EC ;

Ortega, JFF ;

García, GQ .

LIVER TRANSPLANTATION, 2004, 10 (11) :1379-1385

← 1 2 3 4 →