Clinical outcomes and cognitive impairments between progressive supranuclear palsy and multiple system atrophy

被引：6
作者：
Jia, Peifei [1 ,2 ]
Zhang, Jinhong [1 ,3 ,7 ,8 ]
Han, Jiuyan [4 ]
Ji, Yong [5 ,6 ,9 ,10 ]
机构：
[1] Tianjin Med Univ, Clin Coll Neurol Neurosurg & Neurorehabil, Tianjin, Peoples R China
[2] Baotou Med Coll, Dept Neurol, Affiliated Hosp 2, Baotou, Peoples R China
[3] Cangzhou Peoples Hosp, Dept Neurol, Cangzhou, Hebei, Peoples R China
[4] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China
[5] Tianjin Huanhu Hosp, Dept Neurol, Tianjin, Peoples R China
[6] Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Dept Neurol, Beijing, Peoples R China
[7] Tianjin Med Univ, Clin Coll Neurol Neurosurg & Neurorehabil, 22 Qixiangtai Rd, Tianjin 300070, Peoples R China
[8] Cangzhou Peoples Hosp, Dept Neurol, Cangzhou 061000, Hebei, Peoples R China
[9] Tianjin Huanhu Hosp, Dept Neurol, 6 Jizhao Rd, Tianjin 300350, Peoples R China
[10] Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Dept Neurol, 119 South Fourth Ring West Rd, Beijing 100070, Peoples R China
来源：
BRAIN AND BEHAVIOR | 2022年 / 12卷 / 12期
关键词：
cognitive impairments; multiple system atrophy; progressive supranuclear palsy; the mini-mental state examination; the Montreal Cognitive Assessment; PARKINSONIAN-SYNDROMES; DIAGNOSIS; CRITERIA; PREVALENCE; DISEASE;
D O I：
10.1002/brb3.2827
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
BackgroundBoth progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) belong to atypical parkinsonian syndromes. It is important to differentiate these diseases accurately. We compared clinical outcomes and cognitive impairments between PSP and MSA. MethodsEighty-five MSA parkinsonism type (MSA-P) patients and 76 PSP patients participated in this research. The Montreal Cognitive Assessment (MoCA) and the mini-mental state examination (MMSE) evaluated cognitive function. ResultsMSA-P patients had a significantly higher incidence of dyskinesia, fall, urinary symptoms, and constipation, whereas patients with PSP had a higher incidence of tremor and salivation. MSA-P patients had higher MMSE and MoCA scores than PSP patients. The MMSE score showed a diagnostic cut-off score of 24.5 in PSP versus MSA-P. The MoCA score showed a diagnostic cut-off score of 20.5 in PSP versus MSA-P. ConclusionIn conclusion, patients with PSP had differences in the clinical outcomes and cognitive impairments compared with MSA-P patients. PSP patients had more severe cognitive deficits. The score of MMSE and MoCA could be used in distinguishing MSA-P from PSP.
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页数：6
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