Role of the endogenous elastase inhibitor, elafin, in cardiovascular injury From epithelium to endothelium

被引：61

作者：

Alam, Shirjel R. ^{[1
]}

Newby, David E. ^{[1
]}

Henriksen, Peter A. ^{[2
]}

机构：

[1] Univ Edinburgh, Ctr Cardiovasc Sci, British Heart Fdn, John Wheatley Chair Cardiol, Edinburgh EH16 4TJ, Midlothian, Scotland

[2] Royal Infirm Edinburgh NHS Trust, Edinburgh EH16 4TJ, Midlothian, Scotland

来源：

BIOCHEMICAL PHARMACOLOGY | 2012年 / 83卷 / 06期

基金：

英国医学研究理事会;

关键词：

Cardiovascular; Elafin; Elastase; Proteinase-3; Neutrophil; LEUKOCYTE PROTEASE INHIBITOR; ACUTE LUNG INJURY; HUMAN NEUTROPHIL ELASTASE; PROTEINASE-INHIBITOR; MYOCARDIAL-ISCHEMIA; BACTERIAL LIPOPOLYSACCHARIDE; INFLAMMATORY RESPONSES; ACTIVATED NEUTROPHILS; BALLOON ANGIOPLASTY; HUMAN KERATINOCYTES;

D O I：

10.1016/j.bcp.2011.11.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Neutrophils and neutrophil-derived elastases play a major role in the regulation of vascular injury and inflammation, such as ischemia-reperfusion injury. Elafin is an endogenous inhibitor of neutrophil-derived elastases with numerous anti-inflammatory functions that include modulation of inflammatory cytokine release as well as innate and adaptive immunity. It is produced by epithelial tissues including the skin and respiratory system that have adapted to respond to the microbial and chemical insults that lead to inflammation. The production of peptides like elafin with multi-faceted anti-inflammatory activity is an important part of this adaptation. Although not directly expressed within the cardiovascular system itself, pre-clinical studies have suggested therapeutic benefit of elafin in cardiovascular disease. The aim of this review is to highlight the role of neutrophil-derived elastases in vascular inflammation and injury. We will discuss the beneficial effects of elafin inhibition of neutrophil elastase and its extended anti-inflammatory activity in pre-clinical models of inflammatory vascular injury. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：695 / 704

页数：10

共 113 条

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