Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo

被引：47

作者：

Niu Zhanfeng ^{[1
,2
]}

Li Yanhui ^{[3
]}

Fei Zhou ^{[2
]}

Hao Shaocai ^{[1
]}

Li Guangxing ^{[1
]}

Xia Hechun ^{[1
,4
]}

机构：

[1] Ningxia Med Univ, Gen Hosp, Dept Neurosurg, Yinchuan, Peoples R China

[2] Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China

[3] Ningxia Med Univ, Grad Sch, Yinchuan, Peoples R China

[4] Ningxia Med Univ, Incubat Base Natl Key Lab Cerebrocranial Dis, Yinchuan, Peoples R China

来源：

ONCOTARGET | 2015年 / 6卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Per1; Per2; glioma; radiotherapeutic sensitivity; CELL-CYCLE; IONIZING-RADIATION; CANCER; CLOCK; MYC; EXPRESSION; OVEREXPRESSION; SUPPRESSION; PROGRESSION; RHYTHMS;

D O I：

10.18632/oncotarget.3179

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Per1 and Per2 play a key role in regulating the circadian rhythm in mammals. We report here that although both genes were expressed with a circadian rhythm in glioma and normal brain tissue in rats, their expression profiles differed in the two types of tissue. In addition, high expression of Per1 and Per2 in glioma tissue was associated with increased sensitivity to x-irradiation. No such sensitizing effect was observed in normal tissue. Our results suggest that Per1 and Per2 expression may increase the efficacy of radiotherapy against glioma by promoting apoptosis.

引用

页码：9951 / 9958

页数：8

共 50 条

[41] Opposing actions of Per1 and Cry2 in the regulation of Per1 target gene expression in the liver and kidney
Richards, Jacob
All, Sean
Skopis, George
Cheng, Kit-Yan
Compton, Brandy
Srialluri, Nitya
Stow, Lisa
Jeffers, Lauren A.
Gumz, Michelle L.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2013, 305 (07) : R735 - R747
[42] Daily rhythmic variations of VEGF in esophageal squamous cell carcinoma patients: a correlation study of clock gene PER1, PER2 and VEGF expression
Deng, Xia
Li, Guangming
Hu, Xin
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2017, 10 (02): : 1008 - +
[43] Influence of photoperiod duration and light-dark transitions on entrainment of Per1 and Per2 gene and protein expression in subdivisions of the mouse suprachiasmatic nucleus
Sosniyenko, Serhiy
Hut, Roelof A.
Daan, Serge
Sumova, Alena
EUROPEAN JOURNAL OF NEUROSCIENCE, 2009, 30 (09) : 1802 - 1814
[44] Circadian variations of clock gene Per2 and cell cycle genes in different stages of carcinogenesis in golden hamster buccal mucosa
Tan, Xue-Mei
Ye, Hua
Yang, Kai
Chen, Dan
Wang, Qing-Qing
Tang, Hong
Zhao, Ning-Bo
SCIENTIFIC REPORTS, 2015, 5
[45] The Impact of HIF1α on the Per2 Circadian Rhythm in Renal Cancer Cell Lines
Okabe, Takashi
Kumagai, Megumi
Nakajima, Yoshihiro
Shirotake, Suguru
Kodaira, Kiichiro
Oyama, Masafumi
Ueno, Munehisa
Ikeda, Masaaki
PLOS ONE, 2014, 9 (10):
[46] Interactive Organization of the Circadian Core Regulators PER2, BMAL1, CLOCK and PML
Miki, Takao
Zhao, Zhaoyang
Lee, Cheng Chi
SCIENTIFIC REPORTS, 2016, 6
[47] The mammalian circadian clock gene Per2 modulates cell ceatn in response to oxidative stress
Magnone, Maria Chiara
Langmesser, Sonja
Bezdek, April Candice
Tallone, Tiziano
Rusconi, Sandro
Albrecht, Urs
FRONTIERS IN NEUROLOGY, 2015, 5
[48] Dopamine D1 Receptor-Mediated Regulation of Per1, Per2, CLOCK, and BMAL1 Expression in the Suprachiasmatic Nucleus in Adult Male Rats
Mesgar, Somaye
Jameie, Seyed Behnamedin
Aliaghaei, Abbas
Parvardeh, Siavash
Torabi, Abolfazl
Haghparast, Abbas
JOURNAL OF MOLECULAR NEUROSCIENCE, 2022, 72 (03) : 618 - 625
[49] Associated analysis of PER1/TUBB2B with endometrial cancer development caused by circadian rhythm disorders
Wang, Zhaoxia
Wang, Hui
Wang, Zhaojun
He, Simin
Jiang, Zhiping
Yan, Changping
Zhang, Sanyuan
Wang, Tong
MEDICAL ONCOLOGY, 2020, 37 (10)
[50] Direct regulation of Per2 by Roraa: insights into circadian and metabolic interplay in zebrafish
Yang, Miao
Liu, Yan
Zhong, Zhilin
Ou, Yue
Wang, Mingyong
Zhong, Yingbin
Liu, Chao
CELLULAR AND MOLECULAR LIFE SCIENCES, 2025, 82 (01)

← 1 2 3 4 5 →