Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo

被引：47

作者：

Niu Zhanfeng ^{[1
,2
]}

Li Yanhui ^{[3
]}

Fei Zhou ^{[2
]}

Hao Shaocai ^{[1
]}

Li Guangxing ^{[1
]}

Xia Hechun ^{[1
,4
]}

机构：

[1] Ningxia Med Univ, Gen Hosp, Dept Neurosurg, Yinchuan, Peoples R China

[2] Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China

[3] Ningxia Med Univ, Grad Sch, Yinchuan, Peoples R China

[4] Ningxia Med Univ, Incubat Base Natl Key Lab Cerebrocranial Dis, Yinchuan, Peoples R China

来源：

ONCOTARGET | 2015年 / 6卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Per1; Per2; glioma; radiotherapeutic sensitivity; CELL-CYCLE; IONIZING-RADIATION; CANCER; CLOCK; MYC; EXPRESSION; OVEREXPRESSION; SUPPRESSION; PROGRESSION; RHYTHMS;

D O I：

10.18632/oncotarget.3179

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Per1 and Per2 play a key role in regulating the circadian rhythm in mammals. We report here that although both genes were expressed with a circadian rhythm in glioma and normal brain tissue in rats, their expression profiles differed in the two types of tissue. In addition, high expression of Per1 and Per2 in glioma tissue was associated with increased sensitivity to x-irradiation. No such sensitizing effect was observed in normal tissue. Our results suggest that Per1 and Per2 expression may increase the efficacy of radiotherapy against glioma by promoting apoptosis.

引用

页码：9951 / 9958

页数：8

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