Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo

被引：47
|
作者：
Niu Zhanfeng [1 ,2 ]
Li Yanhui [3 ]
Fei Zhou [2 ]
Hao Shaocai [1 ]
Li Guangxing [1 ]
Xia Hechun [1 ,4 ]
机构：
[1] Ningxia Med Univ, Gen Hosp, Dept Neurosurg, Yinchuan, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China
[3] Ningxia Med Univ, Grad Sch, Yinchuan, Peoples R China
[4] Ningxia Med Univ, Incubat Base Natl Key Lab Cerebrocranial Dis, Yinchuan, Peoples R China
来源：
ONCOTARGET | 2015年 / 6卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Per1; Per2; glioma; radiotherapeutic sensitivity; CELL-CYCLE; IONIZING-RADIATION; CANCER; CLOCK; MYC; EXPRESSION; OVEREXPRESSION; SUPPRESSION; PROGRESSION; RHYTHMS;
D O I：
10.18632/oncotarget.3179
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Per1 and Per2 play a key role in regulating the circadian rhythm in mammals. We report here that although both genes were expressed with a circadian rhythm in glioma and normal brain tissue in rats, their expression profiles differed in the two types of tissue. In addition, high expression of Per1 and Per2 in glioma tissue was associated with increased sensitivity to x-irradiation. No such sensitizing effect was observed in normal tissue. Our results suggest that Per1 and Per2 expression may increase the efficacy of radiotherapy against glioma by promoting apoptosis.
引用
收藏
页码：9951 / 9958
页数：8
相关论文
共 50 条
  • [1] The circadian gene expression of Per1 and Per2 and their influence on radiotherapeutic sensitivity of glioma in vitro
    Xia, He-Chun
    Wang, Fan
    Li, Yan-Hui
    Li, Zhang-Ke
    Cao, Shuan-Zhu
    Li, Cai-Yan
    Niu, Zhan-Feng
    FUTURE NEUROLOGY, 2012, 7 (03) : 341 - 348
  • [2] The circadian gene expression of Per1 and Per2 and their influence on radiotherapeutic sensitivity of glioma in vitro
    Xia, He-Chun
    Wang, Fan
    Li, Yan-Hui
    Li, Zhang-Ke
    Cao, Shuan-Zhu
    Li, Cai-Yan
    Niu, Zhan-Feng
    CURRENT DRUG SAFETY, 2012, 7 (03) : 341 - 348
  • [3] The circadian Per1 and Per2 genes influence alcohol reinforcement, and blood alcohol levels
    Gamsby, J. J.
    Templeton, E. L.
    Bonvini, L. A.
    Wang, W.
    Loros, J. J.
    Dunlap, J. C.
    Green, A. I.
    Gulick, D.
    BEHAVIOURAL BRAIN RESEARCH, 2013, 249 : 15 - 21
  • [4] Differential localization of PER1 and PER2 in the brain master circadian clock
    Riddle, Malini
    Mezias, Erica
    Foley, Duncan
    LeSauter, Joseph
    Silver, Rae
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2017, 45 (11) : 1357 - 1367
  • [5] Core circadian clock genes Per1 and Per2 regulate the rhythm in photoreceptor outer segment phagocytosis
    Milicevic, Nemanja
    Hakkari, Ouafa Ait-Hmyed
    Bagchi, Udita
    Sandu, Cristina
    Jongejan, Aldo
    Moerland, Perry D.
    ten Brink, Jacoline B.
    Hicks, David
    Bergen, Arthur A.
    Felder-Schmittbuhl, Marie-Paule
    FASEB JOURNAL, 2021, 35 (07):
  • [6] Search for signals of positive selection of circadian rhythm genes PER1, PER2, PER3 in different human populations
    Mishina, A. I.
    Bakoev, S. Y.
    Oorzhak, A. Y.
    Keskinov, A. A.
    Kabieva, Sh. Sh.
    Korobeinikova, A. V.
    Yudin, V. S.
    Bobrova, M. M.
    Shestakov, D. A.
    Makarov, V. V.
    Getmantseva, L. V.
    VAVILOVSKII ZHURNAL GENETIKI I SELEKTSII, 2024, 28 (06): : 640 - 649
  • [7] Circadian Clock Genes Per1 and Per2 Regulate the Response of Metabolism-Associated Transcripts to Sleep Disruption
    Husse, Jana
    Hintze, Sophie Charlotte
    Eichele, Gregor
    Lehnert, Hendrik
    Oster, Henrik
    PLOS ONE, 2012, 7 (12):
  • [8] Light responsiveness of clock genes, Per1 and Per2, in the olfactory bulb of mice
    Hamada, Toshiyuki
    Honma, Sato
    Honma, Ken-ichi
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 409 (04) : 727 - 731
  • [9] Tumor growth suppression in vivo by overexpression of the circadian component, PER2
    Miyazaki, Koyomi
    Wakabayashi, Miyuki
    Hara, Yasuhiro
    Ishida, Norio
    GENES TO CELLS, 2010, 15 (04) : 351 - 358
  • [10] Per1/Per2 double knockout transcriptome analysis reveals circadian regulation of hepatic lipid metabolism
    Bu, Yiran
    Chen, Si
    Ruan, Mengcheng
    Wu, Libang
    Wang, Hualin
    Li, Na
    Zhao, Xiuju
    Yu, Xiaoli
    Liu, Zhiguo
    FOOD SCIENCE AND HUMAN WELLNESS, 2023, 12 (05) : 1716 - 1729
12345