Adipose tissue inflammation in obesity: a metabolic or immune response?

被引：176

作者：

Stolarczyk, Emilie ^{[1
]}

机构：

[1] Imperial Coll London, Div Diabet Endocrinol & Metab, Hammersmith Campus, London, England

来源：

CURRENT OPINION IN PHARMACOLOGY | 2017年 / 37卷

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

PROMOTE INSULIN-RESISTANCE; REGULATORY T-CELLS; TNF-ALPHA; 3T3-L1; ADIPOCYTES; LEPTIN; MICE; FAT; DIFFERENTIATION; INTERLEUKIN-6; ADIPONECTIN;

D O I：

10.1016/j.coph.2017.08.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Adipose tissue is not only a reservoir for energy, but also an immune organ. In the context of obesity, the development of insulin resistance is now recognised to be initiated by inflammation of the adipose tissue. However, the primary events triggering this inflammation are still unclear, as a complex combination of endocrine and immune factors act to regulate this adipose tissue microenvironment. Below we discuss the different factors involved and how they affect the biology of the adipose tissue in obesity.

引用

页码：35 / 40

页数：6

共 55 条

[1] Morbidity and mortality associated with obesity [J].

Abdelaal, Mahmoud ;

le Roux, Carel W. ;

Docherty, Neil G. .

ANNALS OF TRANSLATIONAL MEDICINE, 2017, 5 (07)

[2] Role of leptin in the neuroendocrine response to fasting [J].

Ahima, RS ;

Prabakaran, D ;

Mantzoros, C ;

Qu, DQ ;

Lowell, B ;

MaratosFlier, E ;

Flier, JS .

NATURE, 1996, 382 (6588) :250-252

[3]

[Anonymous], FEBS LETT

[4] Adipocyte Inflammation Is Essential for Healthy Adipose Tissue Expansion and Remodeling [J].

Asterholm, Ingrid Wernstedt ;

Tao, Caroline ;

Morley, Thomas S. ;

Wang, Qiong A. ;

Delgado-Lopez, Fernando ;

Wang, Zhao V. ;

Scherer, Philipp E. .

CELL METABOLISM, 2014, 20 (01) :103-118

[5]

Bapat SP, 2015, NATURE

[6] TNFα expression of subcutaneous adipose tissue in obese and morbid obese females:: relationship to adipocyte LPL activity and leptin synthesis [J].

Bulló, M ;

García-Lorda, P ;

Peinado-Onsurbe, J ;

Hernández, M ;

Del Castillo, D ;

Argilés, JM ;

Salas-Salvadó, J .

INTERNATIONAL JOURNAL OF OBESITY, 2002, 26 (05) :652-658

[7]

Cipolletta D, 2012, NATURE

[8] Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: Age, diet, and PPARγ effects [J].

Cipolletta, Daniela ;

Cohen, Paul ;

Spiegelman, Bruce M. ;

Benoist, Christophe ;

Mathis, Diane .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (02) :482-487

[9] Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation [J].

Deng, Tuo ;

Lyon, Christopher J. ;

Minze, Laurie J. ;

Lin, Jianxin ;

Zou, Jia ;

Liu, Joey Z. ;

Ren, Yuelan ;

Yin, Zheng ;

Hamilton, Dale J. ;

Reardon, Patrick R. ;

Sherman, Vadim ;

Wang, Helen Y. ;

Phillips, Kevin J. ;

Webb, Paul ;

Wong, Stephen T. C. ;

Wang, Rong-fu ;

Hsueh, Willa A. .

CELL METABOLISM, 2013, 17 (03) :411-422

[10] Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells [J].

Ellingsgaard, Helga ;

Hauselmann, Irina ;

Schuler, Beat ;

Habib, Abdella M. ;

Baggio, Laurie L. ;

Meier, Daniel T. ;

Eppler, Elisabeth ;

Bouzakri, Karim ;

Wueest, Stephan ;

Muller, Yannick D. ;

Hansen, Ann Maria Kruse ;

Reinecke, Manfred ;

Konrad, Daniel ;

Gassmann, Max ;

Reimann, Frank ;

Halban, Philippe A. ;

Gromada, Jesper ;

Drucker, Daniel J. ;

Gribble, Fiona M. ;

Ehses, Jan A. ;

Donath, Marc Y. .

NATURE MEDICINE, 2011, 17 (11) :1481-U1500

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