Effect of ubiquinone Q10 and antioxidant vitamins on free radical oxidation of phospholipids in biological membranes of rat liver

被引：6
|
作者：
Tikhaze, AK [1 ]
Konovalova, GG [1 ]
Lankin, VZ [1 ]
Kaminnyi, AI [1 ]
Kaminnaja, VI [1 ]
Ruuge, EK [1 ]
Kukharchuk, VV [1 ]
机构：
[1] AL Myasnikov Cardiol Inst, Inst Expt Cardiol, Russian Cardiol Res & Prod Complex, Russian Minist Hlth, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2005年 / 140卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
free radical lipid oxidation; ubiquinone Q(10); antioxidant vitamins; tissue antioxidant potential;
D O I：
10.1007/s10517-005-0439-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effects of 30-day peroral treatment with beta-carotene, a complex of antioxidant vitamins (vitamins C and E and provitamin A) and selenium, and solubilized ubiquinone Q(10) on the antioxidant potential in rat liver (ascorbate-dependent free radical oxidation of unsaturated membrane phospholipids). beta-Carotene irrespective of the administration route increased antioxidant potential of the liver by 2-3.5 times. The complex of antioxidant vitamins and selenium increased this parameter by more than 15 times. Antiradical activity in rat liver was extremely high after administration of solubilized ubiquinone Q(10) (increase by more than by 36 times). It can be expected that reduced ubiquinone Q(10) in vivo should produce a more pronounced protective effect due to activity of the system for bioregeneration of this natural antioxidant.
引用
收藏
页码：181 / 183
页数：3
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