Abiesanol A, a novel biflavanol with unique six connective hexacyclic rings isolated from Abies georgei

被引：26

作者：

Yang, Xian-Wen ^{[1
]}

Li, Su-Mei ^{[2
]}

Feng, Lin ^{[3
]}

Shen, Yun-Heng ^{[1
]}

Tian, Jun-Mian ^{[1
]}

Zeng, Hua-Wu ^{[1
]}

Liu, Xiao-Hua ^{[1
]}

Shan, Lei ^{[1
]}

Su, Juan ^{[1
]}

Zhang, Chuan ^{[1
]}

Zhang, Wei-Dong ^{[1
,4
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 200433, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, Dept Ethnobot, Kunming 650204, Peoples R China

[3] Jiangxi Univ Tradit Chinese Med, Dept Pharm, Nanchang 330004, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 19期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Abies georgei; pinaceae; biflavanol; abiesanol A; nitric oxide (NO); RAW264.7; macrophages;

D O I：

10.1016/j.tetlet.2008.03.065

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel biffavanol with unique six connective hexacyclic rings, abiesanol A (1), was isolated from the aerial parts of Abies georgei together with four known flavanols. The structure of new compound was elucidated mainly by the analysis of ID and 2D NMR spectroscopic data. In addition, single-crystal X-ray diffraction analysis was adopted to confirm the structure of abiesanol A (1). In biological assay for inhibitory activities against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, abiesanol A (1) showed potent effects at 50 mu g/mL with the inhibition rate of 43.0%. Under the same concentration, abiesanol A (1) did not show any cytotoxicity against RAW264.7 macrophages. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3042 / 3044

页数：3