ATP-sensitive potassium channels: A model of heteromultimeric potassium channel/receptor assemblies

被引:414
作者
Seino, S [1 ]
机构
[1] Chiba Univ, Grad Sch Med, Dept Mol Med, Chuo Ku, Chiba 2608670, Japan
关键词
inward rectifiers; sulfonylurea receptors; ATP-binding cassette protein superfamily; ADP; glibenclamide;
D O I
10.1146/annurev.physiol.61.1.337
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
ATP-sensitive K+ channels (K-ATP channels) play important roles in many cellular functions by coupling cell metabolism to electrical activity. By cloning members of the novel inwardly rectifying K+ channel subfamily Kir6.0 (Kir6.1 and Kir6.2) and the receptors for sulfonylureas (SUR1 and SUR2), researchers have clarified the molecular structure of K-ATP channels. K-ATP channels comprise two subunits: a Kir6.0 subfamily subunit, which is a member of the inwardly rectifying K+ channel family; and a SUR subunit, which is a member of the ATP-binding cassette (ABC) protein superfamily. K-ATP channels are the first example of a heteromultimeric complex assembled with a K+ channel and a receptor that are structurally unrelated to each other. Since 1995, molecular biological and molecular genetic studies of K-ATP channels have provided insights into the structure-function relationships, molecular regulation, and pathophysiological roles of K-ATP channels.
引用
收藏
页码:337 / 362
页数:26
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