Chiral pyrrolidine derivatives as catalysts in the enantioselective addition of diethylzinc to aldehydes

被引：61
|
作者：
Yang, XW
Shen, JH
Da, CS
Wang, R [1 ]
Choi, MCK
Yang, LW
Wong, KY
机构：
[1] Lanzhou Univ, Union Lab Asymmetr Synth, Lanzhou 730000, Peoples R China
[2] Lanzhou Univ, Dept Biol, Lanzhou 730000, Peoples R China
[3] Hong Kong Polytech Univ, Union Lab Asymmetr Synth, Hong Kong, Peoples R China
[4] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China
来源：
TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 01期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/S0957-4166(98)00497-2
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of pyrrolidine derivatives with beta-amino alcohol moieties prepared from (S)-proline were found to catalyze the enantioselective addition of diethylzinc to aldehydes to yield optically active secondary alcohols with high enantioselectivities. A mechanism accounting for the configurational change with the bulkiness of chiral ligands is proposed. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：133 / 138
页数：6
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