Chiral pyrrolidine derivatives as catalysts in the enantioselective addition of diethylzinc to aldehydes

被引：61

作者：

Yang, XW

Shen, JH

Da, CS

Wang, R ^{[1
]}

Choi, MCK

Yang, LW

Wong, KY

机构：

[1] Lanzhou Univ, Union Lab Asymmetr Synth, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Dept Biol, Lanzhou 730000, Peoples R China

[3] Hong Kong Polytech Univ, Union Lab Asymmetr Synth, Hong Kong, Peoples R China

[4] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 01期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0957-4166(98)00497-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of pyrrolidine derivatives with beta-amino alcohol moieties prepared from (S)-proline were found to catalyze the enantioselective addition of diethylzinc to aldehydes to yield optically active secondary alcohols with high enantioselectivities. A mechanism accounting for the configurational change with the bulkiness of chiral ligands is proposed. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：133 / 138

页数：6

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