Inclusion of CpG adjuvant with plasmid DNA coding for NcGRA7 improves protection against congenital neosporosis

被引：40
作者：
Jenkins, M [1 ]
Parker, C
Tuo, W
Vinyard, B
Dubey, JP
机构：
[1] USDA, ARS, ANRI, Anim Parasit Dis Lab, Beltsville, MD 20705 USA
[2] USDA, ARS, Biometr Consulting Unit, Beltsville, MD 20705 USA
来源：
INFECTION AND IMMUNITY | 2004年 / 72卷 / 03期
关键词：
D O I：
10.1128/IAI.72.3.1817-1819.2004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The present study showed that incorporation of CpG adjuvant into plasmid DNA coding for NcGRA7 antigen resulted in a twofold increase in the level of protection against congenital transfer of Neospora caninum. The level of protection was considerably higher than that observed in pups born from dams immunized with nonrecombinant plasmid.
引用
收藏
页码：1817 / 1819
页数：3
相关论文
共 21 条
  • [1] A POLYGEN™-adjuvanted killed Neospora caninum tachyzoite preparation failed to prevent foetal infection in pregnant cattle following i.v./i.m. experimental tachyzoite challenge
    Andrianarivo, AG
    Rowe, JD
    Barr, BC
    Anderson, ML
    Packham, AE
    Sverlow, KW
    Choromanski, L
    Loui, C
    Grace, A
    Conrad, PA
    [J]. INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2000, 30 (09) : 985 - 990
  • [2] Immunogenicity of a killed whole Neospora caninum tachyzoite preparation formulated with different adjuvants
    Andrianarivo, AG
    Choromanski, L
    McDonough, SP
    Packham, AE
    Conrad, PA
    [J]. INTERNATIONAL JOURNAL FOR PARASITOLOGY, 1999, 29 (10) : 1613 - 1625
  • [3] Vaccination of mice against experimental Neospora caninum infection using NcSAG1- and NcSRS2-based recombinant antigens and DNA vaccines
    Cannas, A
    Naguleswaran, A
    Müller, N
    Eperon, S
    Gottstein, B
    Hemphill, A
    [J]. PARASITOLOGY, 2003, 126 : 303 - 312
  • [4] Cannas A, 2003, J PARASITOL, V89, P44, DOI 10.1645/0022-3395(2003)089[0044:RCIONC]2.0.CO
  • [5] 2
  • [6] Dubey J.P., 2003, J PARASITOL S, V89, pS42
  • [7] Hosmer D. W., 1989, APPL LOGISTIC REGRES, DOI DOI 10.1097/00019514-200604000-00003
  • [8] Immune responses to Neospora caninum and prospects for vaccination
    Innes, EA
    Andrianarivo, AG
    Björkman, C
    Williams, DJL
    Conrad, PA
    [J]. TRENDS IN PARASITOLOGY, 2002, 18 (11) : 497 - 504
  • [9] Neospora caninum: Role for immune cytokines in host immunity
    Khan, IA
    Schwartzman, JD
    Fonseka, S
    Kasper, LH
    [J]. EXPERIMENTAL PARASITOLOGY, 1997, 85 (01) : 24 - 34
  • [10] Klinman Dennis M, 2003, Expert Rev Vaccines, V2, P305, DOI 10.1586/14760584.2.2.305
123