Drug intelligence based on organic impurities in illicit MA samples

被引：55

作者：

Dujourdy, L. ^{[1
]}

Dufey, V. ^{[1
]}

Besacier, F. ^{[1
]}

Miano, N. ^{[1
]}

Marquis, R. ^{[2
]}

Lock, E. ^{[3
]}

Aalberg, L. ^{[4
]}

Dieckmann, S. ^{[5
]}

Zrcek, F. ^{[6
]}

Bozenko, J. S., Jr. ^{[7
]}

机构：

[1] Lab Police Sci Lyon, F-69134 Ecully, France

[2] Univ Lausanne, Inst Police Sci, CH-1015 Lausanne, Switzerland

[3] Netherlands Forens Inst, NL-2490 AA The Hague, Netherlands

[4] Natl Bur Invest, FIN-01301 Vantaa, Finland

[5] Bundeskriminalamt, D-65193 Wiesbaden, Germany

[6] Inst Criminalist Prague, Prague 17089, Czech Republic

[7] Drug Enforcement Adm, Special Testing & Res Lab, Dulles, VA 20166 USA

来源：

FORENSIC SCIENCE INTERNATIONAL | 2008年 / 177卷 / 2-3期

关键词：

drug profiling; MA; organic impurities; GC/MS; statistics; synthesis routes;

D O I：

10.1016/j.forsciint.2007.11.013

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

One major objective of the European project "Collaborative Harmonisation of Methods for Profiling of Amphetamine Type Stimulants" (CHAMP), funded by the sixth framework programme of the European Commission, consisted of the harmonisation of a gas chromatography/mass spectrometry (GUMS) method for the analysis of organic impurities found in illicit methamphetamine (MA) samples in a drug intelligence perspective. Statistical analysis provided a selection of pertinent variables among the 43 organic impurities identified in the chromatograms. As for the 3,4-MethyleneDioxyMethAmphetamine (MDMA) study [1], correlation coefficients were used as a discrimination tool between populations of linked samples (from the same seizure) and unlinked samples (from different seizures). It was also shown that correlation measurements based on Pearson and cosine functions applied to the data pre-treated by normalisation to the sum of peak responses followed by the square root provided excellent discrimination between the two populations. The organic impurities profiling method was proved to be relevant for the characterization of samples from different seizures and their synthesis route patterns. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：153 / 161

页数：9

共 21 条

[1] A study of the use of Ephedra in the manufacture of methamphetamine [J].