Dendritic cells (DC) are professional antigen (Ag)-presenting cells considered traditionally as the passenger leukocytes that, after migration from transplanted tissues, stimulate allospecific naive T cell responses and trigger acute rejection. However there is recent evidence that, besides their role in central T lymphocyte deletion in the thymus, DC perform a crucial function to induce/maintain peripheral T cell tolerance. This paper outlines conceptual models that try to explain how DC may induce/maintain tolerance. It also considers how such ideas have been implemented recently in an effort to generate tolerogenic DC to induce donor Ag-specific tolerance/immunosuppression and prolonged allograft survival. These approaches include genetic engineering of donor- or recipient-derived DC to express molecules capable of promoting tolerance to alloAg. (C) 2001 Academic Press.
机构:
Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USAHematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
Arpinati, M
Green, CL
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机构:Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
Green, CL
Heimfeld, S
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机构:Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
Heimfeld, S
Heuser, JE
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机构:Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
Heuser, JE
Anasetti, C
论文数: 0引用数: 0
h-index: 0
机构:Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
机构:
Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USAHematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
Arpinati, M
Green, CL
论文数: 0引用数: 0
h-index: 0
机构:Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
Green, CL
Heimfeld, S
论文数: 0引用数: 0
h-index: 0
机构:Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
Heimfeld, S
Heuser, JE
论文数: 0引用数: 0
h-index: 0
机构:Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
Heuser, JE
Anasetti, C
论文数: 0引用数: 0
h-index: 0
机构:Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA