Potential of tolerogenic dendritic cells for transplantation

被引:74
作者
Morelli, AE
Hackstein, H
Thomson, AW
机构
[1] Univ Pittsburgh, Med Ctr, Dept Surg, Thomas E Starzl Transplantat Inst, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Med Ctr, Dept Mol Genet & Biochem, Pittsburgh, PA 15213 USA
关键词
dendritic cells; gene therapy; tolerance; transplantation;
D O I
10.1006/smim.2001.0328
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Dendritic cells (DC) are professional antigen (Ag)-presenting cells considered traditionally as the passenger leukocytes that, after migration from transplanted tissues, stimulate allospecific naive T cell responses and trigger acute rejection. However there is recent evidence that, besides their role in central T lymphocyte deletion in the thymus, DC perform a crucial function to induce/maintain peripheral T cell tolerance. This paper outlines conceptual models that try to explain how DC may induce/maintain tolerance. It also considers how such ideas have been implemented recently in an effort to generate tolerogenic DC to induce donor Ag-specific tolerance/immunosuppression and prolonged allograft survival. These approaches include genetic engineering of donor- or recipient-derived DC to express molecules capable of promoting tolerance to alloAg. (C) 2001 Academic Press.
引用
收藏
页码:323 / 335
页数:13
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