Radical C-H Bond Oxidation Initiated Intramolecular Cyclization of Glycine Esters: Construction of Dihydroquinoline Skeletons

被引：5

作者：

Chen, Qian ^{[1
]}

Zhang, Shuwei ^{[1
]}

Zhang, Ting ^{[1
]}

He, Kaixuan ^{[1
]}

Yuan, Yu ^{[1
]}

Jia, Xiaodong ^{[1
]}

机构：

[1] Yangzhou Univ, Sch Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 8卷 / 01期

基金：

中国国家自然科学基金;

关键词：

sp(3) C-H activation; radical cation salt; aerobic oxidation; cyclization; dihydroquinoline; DERIVATIVES; FUNCTIONALIZATION; ANALOGS; PODOPHYLLOTOXIN; ACTIVATION; QUINOLINE;

D O I：

10.1002/ajoc.201800596

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient construction of dihydroquinoline derivatives was realized through radical cation salt-initiated C-H bond oxidation of unsaturated glycine esters. In the presence of dioxygen, the sp(3) C-H bond adjacent to nitrogen was oxidized, followed by cascade cyclization, affording the desired dihydroquinoline products. The mechanistic investigation revealed that a radical intermediate was involved in this reaction.

引用

页码：115 / 118

页数：4

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