NMDA and AMPA receptor physiology and role in visceral hypersensitivity: a review

被引：9

作者：

Cheng, Fangli ^{[1
]}

Du, Lijun ^{[1
]}

Kim, John J. ^{[2
]}

Zhu, Feng ^{[3
]}

He, Huiqin ^{[1
]}

Dai, Ning ^{[1
]}

机构：

[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 East Qingchun Rd, Hangzhou 310016, Zhejiang, Peoples R China

[2] Loma Linda Univ Hlth, Div Gastroenterol, Loma Linda, CA USA

[3] Zhejiang Univ City Coll, Sch Med, Hangzhou, Peoples R China

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 2022年 / 34卷 / 05期

基金：

中国国家自然科学基金;

关键词：

alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors; functional gastrointestinal diseases; N-methyl-d-aspartate receptors; visceral hypersensitivity; LONG-TERM POTENTIATION; IRRITABLE-BOWEL-SYNDROME; DORSAL-HORN NEURONS; NEUROTROPHIC FACTOR; SYNAPTIC PLASTICITY; SPINAL-CORD; PAIN HYPERSENSITIVITY; FUNCTIONAL DYSPEPSIA; NR2B SUBUNIT; CENTRAL SENSITIZATION;

D O I：

10.1097/MEG.0000000000002351

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

N-methyl-d-aspartate receptors (NMDARs) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) are excitatory neurotransmission receptors of the central nervous system and play vital roles in synaptic plasticity. Although not fully elucidated, visceral hypersensitivity is one of the most well-characterized pathophysiologic abnormalities of functional gastrointestinal diseases and appears to be associated with increased synaptic plasticity. In this study, we review the updated findings on the physiology of NMDARs and AMPARs and their relation to visceral hypersensitivity, which propose directions for future research in this field with evolving importance.

引用

页码：471 / 477

页数：7

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