Germ granules and gene regulation in the Caenorhabditis elegans germline

被引：27
|
作者：
Phillips, Carolyn M. [1 ]
Updike, Dustin L. [2 ]
机构：
[1] Univ Southern Calif, Dept Biol Sci, Los Angeles, CA 90089 USA
[2] Mt Desert Isl Biol Lab, Bar Harbor, ME 04672 USA
来源：
GENETICS | 2022年 / 220卷 / 03期
关键词：
C; elegans; germline; germ granules; P granules; Mutator foci; Z granules; piRNAs; WormBook; C; ELEGANS; RNA INTERFERENCE; P-GRANULES; MESSENGER-RNA; EPIGENETIC MEMORY; CELL IMMORTALITY; LIQUID DROPLETS; NUCLEAR-PORES; PROTEIN; PROMOTES;
D O I：
10.1093/genetics/iyab195
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The transparency of Caenorhabditis elegans provides a unique window to observe and study the function of germ granules. Germ granules are specialized ribonucleoprotein (RNP) assemblies specific to the germline cytoplasm, and they are largely conserved across Metazoa. Within the germline cytoplasm, they are positioned to regulate mRNA abundance, translation, small RNA production, and cytoplasmic inheritance to help specify and maintain germline identity across generations. Here we provide an overview of germ granules and focus on the significance of more recent observations that describe how they further demix into sub-granules, each with unique compositions and functions.
引用
收藏
页数：16
相关论文
共 50 条
  • [1] Germ Granules Prevent Accumulation of Somatic Transcripts in the Adult Caenorhabditis elegans Germline
    Knutson, Andrew Kekupa'a
    Egelhofer, Thea
    Rechtsteiner, Andreas
    Strome, Susan
    GENETICS, 2017, 206 (01) : 163 - 178
  • [2] Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules
    Marnik, Elisabeth A.
    Fuqua, J. Heath
    Sharp, Catherine S.
    Rochester, Jesse D.
    Xu, Emily L.
    Holbrook, Sarah E.
    Updike, Dustin L.
    GENETICS, 2019, 213 (03) : 923 - 939
  • [3] RNAi Screen Identifies Novel Regulators of RNP Granules in the Caenorhabditis elegans Germ Line
    Wood, Megan P.
    Hollis, Angela
    Severance, Ashley L.
    Karrick, Megan L.
    Schisa, Jennifer A.
    G3-GENES GENOMES GENETICS, 2016, 6 (08): : 2643 - 2654
  • [4] Launching the germline in Caenorhabditis elegans:: regulation of gene expression in early germ cells
    Seydoux, G
    Strome, S
    DEVELOPMENT, 1999, 126 (15): : 3275 - 3283
  • [5] Caenorhabditis elegans germ granules are present in distinct and assemble in a hierarchical manner
    Uebel, Celja J.
    Rajeev, Sanjana
    Phillips, Carolyn M.
    DEVELOPMENT, 2023, 150 (24):
  • [6] C. elegans germ granules sculpt both germline and somatic RNAome
    Price, Ian F.
    Wagner, Jillian A.
    Pastore, Benjamin
    Hertz, Hannah L.
    Tang, Wen
    NATURE COMMUNICATIONS, 2023, 14 (01)
  • [7] Connecting the Dots: Linking Caenorhabditis elegans Small RNA Pathways and Germ Granules
    Sundby, Adam E.
    Molnar, Ruxandra, I
    Claycomb, Julie M.
    TRENDS IN CELL BIOLOGY, 2021, 31 (05) : 387 - 401
  • [8] Multigenerational Regulation of the Caenorhabditis elegans Chromatin Landscape by Germline Small RNAs
    Weiser, Natasha E.
    Kim, John K.
    ANNUAL REVIEW OF GENETICS, VOL 53, 2019, 53 : 289 - 311
  • [9] A Forward Genetic Screen for Suppressors of Somatic P Granules in Caenorhabditis elegans
    Kelly, Ashley L.
    Senter-Zapata, Michael J.
    Campbell, Anne C.
    Lust, Hannah E.
    Theriault, Monique E.
    Andralojc, Karolina M.
    Updike, Dustin L.
    G3-GENES GENOMES GENETICS, 2015, 5 (10): : 2209 - 2215
  • [10] mRNA localization is linked to translation regulation in the Caenorhabditis elegans germ lineage
    Parker, Dylan M.
    Winkenbach, Lindsay P.
    Boyson, Sam
    Saxton, Matthew N.
    Daidone, Camryn
    Al-Mazaydeh, Zainab A.
    Nishimura, Marc T.
    Mueller, Florian
    Nishimura, Erin Osborne
    DEVELOPMENT, 2020, 147 (13):
12345