EFFICIENT SYNTHESIS OF NEW PEPTIDYL CHLOROMETHYL KETONES FOR THE APPLICATION OF PROTEINASE K INHIBITORS

被引：1
作者：
Kore, Anilkumar R. [1 ]
Shanmugasundaram, Muthian [1 ]
机构：
[1] Life Technol Inc, Bioorgan Chem Div, Austin, TX 78744 USA
来源：
SYNTHETIC COMMUNICATIONS | 2012年 / 42卷 / 01期
关键词：
Chloromethyl ketones; isoleucine; proteinase K inhibitor; serine protease; SITE-SPECIFIC INHIBITORS; ALPHA-CHYMOTRYPSIN; SERINE PROTEASES; INACTIVATION;
D O I：
10.1080/00397911.2010.521290
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of a new series of peptidyl chloromethyl ketones such as MeOSuc-Ala-Ala-Pro-Ile-CH2Cl (AAPI) and MeOSuc-Ala-Ala-Ala-Pro-Ile-CH2Cl (AAAPI) is described.
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收藏
页码：40 / 45
页数：6
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