Study of the kinetic parameters for synthesis and hydrolysis of pharmacologically active salicin isomer catalyzed by baker's yeast maltase

被引：5

作者：

Velickovic, D. V. ^{[1
]}

Dimitrijevic, A. S. ^{[1
]}

Bihelovic, F. J. ^{[1
]}

Jankov, R. M. ^{[1
]}

Milosavic, N. ^{[1
]}

机构：

[1] Univ Belgrade, Fac Chem, Innovat Ctr, Belgrade, Serbia

来源：

RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A | 2011年 / 85卷 / 13期

关键词：

synthesis and hydrolysis of salicin isomer; catalysis by maltase; kinetic parameters; ENZYMATIC-SYNTHESIS; ALPHA-GLUCOSIDASE; ANALOGS; VMAX;

D O I：

10.1134/S0036024411130346

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

One of the key elements for understanding enzyme reactions is determination of its kinetic parameters. Since transglucosylation is kinetically controlled reaction, besides the reaction of synthesis, very important is the reaction of enzymatic hydrolysis of created product. Therefore, in this study, kinetic parameters for synthesis and secondary hydrolysis of pharmacologically active alpha isosalicin by baker's yeast maltase were calculated, and it was shown that specifity of maltase for hydrolysis is approximately 150 times higher then for synthesis.

引用

页码：2317 / 2321

页数：5

共 2 条

[1] Study of the kinetic parameters for synthesis and hydrolysis of pharmacologically active salicin isomer catalyzed by baker’s yeast maltase
D. V. Veličković
A. S. Dimitrijević
F. J. Bihelović
R. M. Jankov
N. Milosavić
Russian Journal of Physical Chemistry A, 2011, 85 : 2317 - 2321
[2] Baker's yeast catalyzed one-pot synthesis of bioactive 2-[benzylidene(or pyrazol-4-ylmethylene) hydrazono]-1,3-thiazolidin-4-one-5-yl-acetic acids
Chavan, Anusaya S.
Kharat, Arun S.
Bhosle, Manisha R.
Mane, Ramrao A.
HETEROCYCLIC COMMUNICATIONS, 2018, 24 (02) : 103 - 107

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