Intramolecular azomethine ylide cycloaddition reactions to give octahydroindoles

被引：41
作者：
Coldham, I
Crapnell, KM
Moseley, JD
Rabot, R
机构：
[1] Univ Exeter, Sch Chem, Exeter EX4 4QD, Devon, England
[2] AstraZeneca Pharmaceut, Proc R&D Dept, Avlon Works, Bristol BS10 7ZE, Avon, England
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2001年 / 15期
关键词：
D O I：
10.1039/b104390k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The aldehyde 2-formyl-2-(pent-4-enyl)-1,3-dithiane 1, containing both alkene and aldehyde functional groups, is a good substrate for intramolecular dipolar cycloaddition reactions after condensation with various N-alkyl alpha -amino-esters. This paper reports the optimization, scope and stereoselectivity of this reaction to give octahydroindoles (2-azabicyclo[4.3.0]nonanes).
引用
收藏
页码：1758 / 1763
页数：6
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