Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults

被引：33
作者：
Bittner, Nora [1 ,2 ]
Jockwitz, Christiane [1 ,3 ,4 ]
Muehleisen, Thomas W. [2 ,5 ,6 ]
Hoffstaedter, Felix [2 ,7 ]
Eickhoff, Simon B. [2 ,7 ]
Moebus, Susanne [8 ]
Bayen, Ute J. [9 ]
Cichon, Sven [2 ,6 ,10 ]
Zilles, Karl [2 ,4 ]
Amunts, Katrin [2 ,4 ,5 ]
Caspers, Svenja [1 ,2 ,4 ]
机构：
[1] Heinrich Heine Univ Duesseldorf, Med Fac, Inst Anat 1, D-40225 Dusseldorf, Germany
[2] Res Ctr Juelich, Inst Neurosci & Med INM 1 INM 7, D-52425 Julich, Germany
[3] Rhein Westfal TH Aachen, Dept Psychiat Psychotherapy & Psychosomat, D-52074 Aachen, Germany
[4] Juelich Aachen Res Alliance, JARA BRAIN, D-52425 Julich, Germany
[5] Heinrich Heine Univ Duesseldorf, C&O Vogt Inst Brain Res, D-40225 Dusseldorf, Germany
[6] Univ Basel, Dept Biomed, Human Genom Res Grp, CH-4031 Basel, Switzerland
[7] Heinrich Heine Univ Duesseldorf, Inst Syst Neurosci, D-40225 Dusseldorf, Germany
[8] Univ Duisburg Essen, Inst Med Informat Biometry & Epidemiol, D-45122 Essen, Germany
[9] Heinrich Heine Univ Duesseldorf, Inst Expt Psychol, Math & Cognit Psychol, D-40225 Dusseldorf, Germany
[10] Univ Hosp Basel, Inst Med Genet & Pathol, CH-4031 Basel, Switzerland
来源：
NATURE COMMUNICATIONS | 2019年 / 10卷 / 1期
基金：
瑞士国家科学基金会; 欧盟地平线“2020”;
关键词：
SURFACE-BASED ANALYSIS; ALCOHOL-CONSUMPTION; ALZHEIMERS-DISEASE; CEREBRAL-CORTEX; SMOKING; STATE; MOTOR; FITNESS; NEUROPLASTICITY; SEGMENTATION;
D O I：
10.1038/s41467-019-08500-x
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Lifestyle contributes to inter-individual variability in brain aging, but previous studies focused on the effects of single lifestyle variables. Here, we studied the combined and individual contributions of four lifestyle variables - alcohol consumption, smoking, physical activity, and social integration - to brain structure and functional connectivity in a population-based cohort of 549 older adults. A combined lifestyle risk score was associated with decreased gyrification in left premotor and right prefrontal cortex, and higher functional connectivity to sensorimotor and prefrontal cortex. While structural differences were driven by alcohol consumption, physical activity, and social integration, higher functional connectivity was driven by smoking. Results suggest that combining differentially contributing lifestyle variables may be more than the sum of its parts. Associations generally were neither altered by adjustment for genetic risk, nor by depressive symptomatology or education, underlining the relevance of daily habits for brain health.
引用
收藏
页数：13
相关论文
共 71 条
  • [1] Functional coupling underlying motor and cognitive functions of the dorsal premotor cortex
    Abe, Mitsunari
    Hanakawa, Takashi
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2009, 198 (01) : 13 - 23
  • [2] COMPENDIUM OF PHYSICAL ACTIVITIES - CLASSIFICATION OF ENERGY COSTS OF HUMAN PHYSICAL ACTIVITIES
    AINSWORTH, BE
    HASKELL, WL
    LEON, AS
    JACOBS, DR
    MONTOYE, HJ
    SALLIS, JF
    PAFFENBARGER, RS
    [J]. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 1993, 25 (01) : 71 - 80
  • [3] Smoking is associated with reduced cortical regional gray matter density in brain regions associated with incipient Alzheimer disease
    Almeida, Osvaldo P.
    Garrido, Griselda J.
    Lautenschlager, Nicola T.
    Hulse, Gary K.
    Jamrozik, Konrad
    Flicker, Leon
    [J]. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2008, 16 (01) : 92 - 98
  • [4] Amunts K, 1997, HUM BRAIN MAPP, V5, P206, DOI 10.1002/(SICI)1097-0193(1997)5:3<206::AID-HBM5>3.0.CO
  • [5] 2-7
  • [6] Alterations in the thickness of motor cortical subregions after motor-skill learning and exercise
    Anderson, BJ
    Eckburg, PB
    Relucio, KI
    [J]. LEARNING & MEMORY, 2002, 9 (01) : 1 - 9
  • [7] [Anonymous], SOCIAL EXCLUSION
  • [8] Unified segmentation
    Ashburner, J
    Friston, KJ
    [J]. NEUROIMAGE, 2005, 26 (03) : 839 - 851
  • [9] The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study
    Bennett, DA
    Schneider, JA
    Tang, YX
    Arnold, SE
    Wilson, RS
    [J]. LANCET NEUROLOGY, 2006, 5 (05) : 406 - 412
  • [10] Social integration and mortality: A prospective study of French employees of electricity of France-gas of France
    Berkman, LF
    Melchior, M
    Chastang, JF
    Niedhammer, I
    Leclerc, A
    Goldberg, M
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 2004, 159 (02) : 167 - 174
12345678