Comparison of Enzyme Immunoassays for Detection of Antibodies to Hepatitis D Virus in Serum

被引：14

作者：

Chow, Siu-Kei ^{[1
,5
]}

Atienza, Ederlyn E. ^{[1
]}

Cook, Linda ^{[1
]}

Prince, Harry ^{[2
,6
]}

Slev, Patricia ^{[3
]}

Lape-Nixon, Mary ^{[2
]}

Jerome, Keith R. ^{[1
,4
]}

机构：

[1] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA

[2] Focus Diagnost Reference Lab, San Juan Capistrano, CA USA

[3] Univ Utah, Dept Pathol, Salt Lake City, UT USA

[4] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Inst, Seattle, WA 98104 USA

[5] MultiCare Hlth Syst, Tacoma, WA USA

[6] Viracor IBT Labs, Los Angeles, CA USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2016年 / 23卷 / 08期

关键词：

DELTA-ANTIGEN; B-VIRUS; INFECTION; ASSAY; HDV;

D O I：

10.1128/CVI.00028-16

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Serology remains critical for diagnosing hepatitis D virus (HDV) infection, which affects 15 to 20 million people worldwide, but the literature on characterizing commercial enzyme immunoassays (EIAs) dates back to 15 years ago. We evaluated 2 commercial EIAs currently available for detecting anti-HDV antibodies. The DiaSorin assay demonstrated 100% sensitivity and specificity. Using a modified cutoff value, the Cusabio assay demonstrated a sensitivity of 81.3% and specificity of 90.9%. Our data show that recently developed EIAs are reliable for anti-HDV antibody detection.

引用

页码：732 / 734

页数：3

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