New Approaches in the Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Hepatocytes

被引：61

作者：

Behbahan, Iman Saramipoor ^{[1
]}

Duan, Yuyou ^{[1
]}

Lam, Alexander ^{[1
]}

Khoobyari, Shiva ^{[1
]}

Ma, Xiaocui ^{[1
]}

Ahuja, Tijess P. ^{[1
]}

Zern, Mark A. ^{[1
]}

机构：

[1] Univ Calif Davis, Med Ctr, Dept Internal Med, Transplant Res Program, Sacramento, CA 95817 USA

来源：

STEM CELL REVIEWS AND REPORTS | 2011年 / 7卷 / 03期

关键词：

Hepatocyte; Hepatocyte differentiation; Hepatocyte transplantation; Human embryonic stem cells; Induced pluripotent stem cells; HIGHLY EFFICIENT DIFFERENTIATION; HUMAN ES CELLS; IN-VITRO; FUNCTIONAL HEPATOCYTES; LIVER-REGENERATION; HEPATIC ENDODERM; GROWTH-FACTORS; DIRECTED DIFFERENTIATION; DEFINITIVE ENDODERM; DEFINED CONDITIONS;

D O I：

10.1007/s12015-010-9216-4

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Orthotropic liver transplantation is the only established treatment for end-stage liver diseases. Utilization of hepatocyte transplantation and bio-artificial liver devices as alternative therapeutic approaches requires an unlimited source of hepatocytes. Stem cells, especially embryonic stem cells, possessing the ability to produce functional hepatocytes for clinical applications and drug development, may provide the answer to this problem. New discoveries in the mechanisms of liver development and the emergence of induced pluripotent stem cells in 2006 have provided novel insights into hepatocyte differentiation and the use of stem cells for therapeutic applications. This review is aimed towards providing scientists and physicians with the latest advancements in this rapidly progressing field.

引用

页码：748 / 759

页数：12

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