Mitochondrial DNA sequence phylogeny of 4 populations of the widely distributed cynomolgus macaque (Macaca fascicularis fascicularis)

被引:66
作者
Blancher, Antoine [1 ,2 ]
Bonhomme, Maxime [3 ]
Crouau-Roy, Brigitte [3 ]
Terao, Keiji [4 ]
Kitano, Takashi [5 ]
Saitou, Naruya [5 ]
机构
[1] Univ Toulouse 3, Immunogenet Mol Lab, F-31062 Toulouse, France
[2] Hop Rangueil, Immunol Lab, TSA 50032, F-31059 Toulouse 9, France
[3] Univ Toulouse 3, CNRS, UMR 5174, Lab Evolut & Diversite Biol, F-31062 Toulouse, France
[4] Natl Inst Infect Dis, Ctr Primate, Tsukuba, Ibaraki 3050843, Japan
[5] Natl Inst Genet, Div Populat Genet, Mishima, Shizuoka 4118540, Japan
关键词
D O I
10.1093/jhered/esn003
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We studied the mitochondrial DNA (mtDNA) polymorphism of 304 Macaca fascicularis fascicularis (M. f. fascicularis) individuals, representative of 4 cynomolgus macaque populations (Indochina, Indonesia, Philippines, and Mauritius). By sequencing a 590-bp fragment in the hypervariable II region of the D-loop region, we defined 70 haplotypes. The homologous region was also characterized in 22 Chinese Macaca mulatta and 2 Macaca sylvanus. The phylogenetic analysis confirms the monophyly of M. f. fascicularis and defines 2 haplotype groups inside the M. f. fascicularis clade: one "insular," encompassing 6 Philippines, 2 Mauritius, and 31 Indonesian haplotypes, the other "continental" that contains all Indochinese and 6 Indonesian haplotypes. Continental and insular group divergence time was estimated to be approximately 10(6) years before present (BP). Among Indonesian haplotypes, some have a continental origin. This suggests either direct migration from mainland to Indonesia or that remnant lineages from an ancient population genetically close to the mainland (i.e., in the Sunda Shelf, < 550 000 years BP) were subsequently brought southward to Indonesia. The low nucleotide diversity in the Philippines population suggests a bottleneck following colonization by Indonesian individuals, around 110 000 years BP. mtDNA and further observations of nuclear genetic data corroborate the mixed origin (Indonesian/continental) hypothesis of Mauritius individuals and a population bottleneck.
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页码:254 / 264
页数:11
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