Immunocyte Ca2+ influx system mediated by LTRPC2

被引：376
作者：
Sano, Y [1 ]
Inamura, K [1 ]
Miyake, A [1 ]
Mochizuki, S [1 ]
Yokoi, H [1 ]
Matsushime, H [1 ]
Furuichi, K [1 ]
机构：
[1] Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Mol Med Labs, Tsukuba, Ibaraki 3058585, Japan
来源：
SCIENCE | 2001年 / 293卷 / 5533期
关键词：
D O I：
10.1126/science.1062473
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We characterized an activation mechanism of the human LTRPC2 protein, a member of the transient receptor potential family of ion channels, and demonstrated that LTRPC2 mediates Call influx into immunocytes. Intracellular pyrimidine nucleotides, adenosine 5'-diphosphoribose (ADPR), and nicotinamide adenine dinucleotide (NAD), directly activated LTRPC2, which functioned as a Ca2+-permeable nonselective cation channel and enabled Ca2+ influx into cells. This activation was suppressed by intracellular adenosine triphosphate. These results reveal that ADPR and NAD act as intracellular messengers and may have an important role in Ca2+ influx by activating LTRPC2 in immunocytes.
引用
收藏
页码：1327 / 1330
页数：4
相关论文
共 25 条
  • [1] Metabolic stress reversibly activates the Drosophila light-sensitive channels TRP and TRPL in vivo
    Agam, K
    von Campenhausen, M
    Levy, S
    Ben-Ami, HC
    Cook, B
    Kirschfeld, K
    Minke, B
    [J]. JOURNAL OF NEUROSCIENCE, 2000, 20 (15) : 5748 - 5755
  • [2] The MutT proteins or ''nudix'' hydrolases, a family of versatile, widely distributed, ''housecleaning'' enzymes
    Bessman, MJ
    Frick, DN
    OHandley, SF
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (41) : 25059 - 25062
  • [3] ISOLATION OF A PUTATIVE PHOSPHOLIPASE-C GENE OF DROSOPHILA, NORPA, AND ITS ROLE IN PHOTOTRANSDUCTION
    BLOOMQUIST, BT
    SHORTRIDGE, RD
    SCHNEUWLY, S
    PERDEW, M
    MONTELL, C
    STELLER, H
    RUBIN, G
    PAK, WL
    [J]. CELL, 1988, 54 (05) : 723 - 733
  • [4] Duncan LM, 1998, CANCER RES, V58, P1515
  • [5] T-CELL DEVELOPMENT AND TRANSMEMBRANE SIGNALING - CHANGING BIOLOGICAL RESPONSES THROUGH AN UNCHANGING RECEPTOR
    FINKEL, TH
    KUBO, RT
    CAMBIER, JC
    [J]. IMMUNOLOGY TODAY, 1991, 12 (02): : 79 - 85
  • [6] Cyclic ADP-ribose
    Guse, AH
    [J]. JOURNAL OF MOLECULAR MEDICINE-JMM, 2000, 78 (01): : 26 - 35
  • [7] Ca2+ signaling in T-lymphocytes
    Guse, AH
    [J]. CRITICAL REVIEWS IN IMMUNOLOGY, 1998, 18 (05) : 419 - 448
  • [8] Interaction of two classes of ADP-ribose transfer reactions in immune signaling
    Han, MK
    Cho, YS
    Kim, YS
    Yim, CY
    Kim, UH
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (27) : 20799 - 20805
  • [9] From worm to man: three subfamilies of TRP channels
    Harteneck, C
    Plant, TD
    Schultz, G
    [J]. TRENDS IN NEUROSCIENCES, 2000, 23 (04) : 159 - 166
  • [10] Transient receptor potential channels as molecular substrates of receptor-mediated cation entry
    Hofmann, T
    Schaefer, M
    Schultz, G
    Gudermann, T
    [J]. JOURNAL OF MOLECULAR MEDICINE-JMM, 2000, 78 (01): : 14 - 25
123