Cannabis-related allergies: An international overview and consensus recommendations

被引：30

作者：

Skypala, Isabel J. ^{[1
,2
]}

Jeimy, Samira ^{[3
]}

Brucker, Hannelore ^{[4
]}

Nayak, Ajay P. ^{[5
,6
]}

Decuyper, Ine I. ^{[7
]}

Bernstein, Jonathan A. ^{[8
,9
]}

Connors, Lori ^{[10
]}

Kanani, Amin ^{[11
]}

Klimek, Ludger ^{[12
]}

Lo, Shun Chi Ryan ^{[11
]}

Murphy, Kevin R. ^{[13
]}

Nanda, Anil ^{[14
,15
]}

Poole, Jill A. ^{[16
]}

Walusiak-Skorupa, Jolanta ^{[17
]}

Sussman, Gordon ^{[18
,19
]}

Zeiger, Joanna S. ^{[20
]}

Goodman, Richard E. ^{[21
]}

Ellis, Anne K. ^{[22
]}

Silvers, William S. ^{[23
]}

Ebo, Didier G. ^{[24
,25
,26
,27
]}

机构：

[1] Royal Brompton & Harefield Hosp, Dept Allergy & Clin Immunol, Sydney St, London SW3 6NP, England

[2] Imperial Coll, London, England

[3] Western Univ, Dept Med, Div Clin Immunol & Allergy, London, ON, Canada

[4] Southdale Allergy & Asthma Clin, Minneapolis, MN USA

[5] Thomas Jefferson Univ, Ctr Translat Med, Philadelphia, PA 19107 USA

[6] Thomas Jefferson Univ, Div Pulm Allergy & Crit Care Med, Dept Med, Jane & Leonard Korman Resp Inst, Philadelphia, PA 19107 USA

[7] Univ Antwerp, Univ Hosp Antwerp, Fac Med & Hlth Sci, Dept Pediat, Antwerp, Belgium

[8] Univ Cincinnati, Coll Med, Dept Internal Med, Allergy Sect,Div Immunol, Cincinnati, OH USA

[9] Bernstein Clin Res Ctr, Bernstein Allergy Grp, Cincinnati, OH USA

[10] Dalhousie Univ, Dept Med, Halifax, NS, Canada

[11] Univ British Columbia, Dept Med, Div Allergy & Immunol, Vancouver, BC, Canada

[12] Ctr Rhinol & Allergy, Wiesbaden, Germany

[13] Boys Town Natl Res Hosp, Div Allergy Asthma & Pediat Pulmonol, Dept Pediat, Omaha, NE 68131 USA

[14] Lewisville & Flower Mound, Asthma & Allergy Ctr, Dallas, TX USA

[15] Univ Texas Southwestern Med Ctr, Div Allergy & Immunol, Dallas, TX USA

[16] Univ Nebraska Med Ctr, Div Allergy & Immunol, Dept Med, Omaha, NE USA

[17] Nofer Inst Occupat Med, Dept Occupat Med & Environm Hlth, Lodz, Poland

[18] Univ Toronto, Dept Med, Toronto, ON, Canada

[19] Univ Toronto, Div Clin Immunol & Allergy, Toronto, ON, Canada

[20] Canna Res Fdn, Boulder, CO USA

[21] Univ Nebraska, Food Allergy Res & Resource Program, Lincoln, NE USA

[22] Queens Univ, Dept Med, Div Allergy & Immunol, Kingston, ON, Canada

[23] Univ Colorado, Div Allergy Clin Immunol, Sch Med, Aurora, CO USA

[24] Univ Antwerp, Fac Med & Hlth Sci, Dept Immunol Allergol Rheumatol, Antwerp, Belgium

[25] Univ Antwerp, Infla Med Ctr Excellence, Antwerp, Belgium

[26] Antwerp Univ Hosp, Dept Immunol Allergol Rheumatol, Antwerp, Belgium

[27] AZ Jan Palfijn Gent, Dept Immunol & Allergol, Ghent, Belgium

来源：

ALLERGY | 2022年 / 77卷 / 07期

关键词：

allergy diagnosis; allergy treament; cannabis allergy; IgE; occupational allergies; LIPID TRANSFER PROTEIN; HYPERSENSITIVITY REACTIONS; CONTACT URTICARIA; FOOD ALLERGY; PLANT-FOODS; IGE-BINDING; SATIVA; MARIJUANA; SENSITIZATION; HEMP;

D O I：

10.1111/all.15237

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Cannabis is the most widely used recreational drug in the world. Cannabis sativa and Cannabis indica have been selectively bred to develop their psychoactive properties. The increasing use in many countries has been accelerated by the COVID-19 pandemic. Cannabis can provoke both type 1 and type 4 allergic reactions. Officially recognized allergens include a pathogenesis-related class 10 allergen, profilin, and a nonspecific lipid transfer protein. Other allergens may also be relevant, and recognition of allergens may vary between countries and continents. Cannabis also has the potential to provoke allergic cross-reactions to plant foods. Since cannabis is an illegal substance in many countries, research has been hampered, leading to challenges in diagnosis since no commercial extracts are available for testing. Even in countries such as Canada, where cannabis is legalized, diagnosis may rely solely on the purchase of cannabis for prick-to-prick skin tests. Management consists of avoidance, with legal issues hindering the development of other treatments such as immunotherapy. Education of healthcare professionals is similarly lacking. This review aimed to summarize the current status of cannabis allergy and proposes recommendations for the future management of this global issue.

引用

页码：2038 / 2052

页数：15

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