Compatibility of ticagrelor with pharmaceutical excipients studied with thermal and spectroscopic techniques

被引：0

作者：

Zhao, Jing ^{[1
]}

Shen, Jinhai ^{[1
]}

Gan, Meiyu ^{[1
]}

Huang, Cuiting ^{[1
]}

You, Qihua ^{[1
]}

机构：

[1] Xiamen Huaxia Univ, Coll Environm & Publ Hlth, Xiamen 361024, Peoples R China

来源：

PHARMAZIE | 2019年 / 74卷 / 10期

关键词：

DIFFERENTIAL SCANNING CALORIMETRY; PRASUGREL ACHIEVES GREATER; ASPIRIN-TREATED PATIENTS; ACUTE CORONARY SYNDROMES; ANTIPLATELET THERAPY; PLATELET INHIBITION; CLOPIDOGREL; INTERVENTIONS; KETOPROFEN; SOCIETY;

D O I：

10.1691/ph.2019.9070

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The compatibility between ticagrelor and selected excipients (mannitol, calcium phosphate tribasic, sodium carboxymethyl starch, hydroxypropyl cellulose and magnesium stearate) was investigated by differential scanning calorimetry. The compatibility was further corroborated by Raman spectroscopy and isothermal stress testing experiments. These results revealed that ticagrelor has high compatibility with mannitol, calcium phosphate tribasic, sodium carboxymethyl starch, hydroxypropyl cellulose and magnesium stearate.

引用

页码：583 / 589

页数：7

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