Regulation of FoxP3+ regulatory T cells and Th17 cells by retinoids

被引:43
作者
Kim, Chang H. [1 ]
机构
[1] Purdue Univ, Purdue Canc Ctr, Dept Comparat Pathobiol, Lab Immunol & Hematopoiesis, W Lafayette, IN 47907 USA
来源
CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2008年
关键词
D O I
10.1155/2008/416910
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Vitamin A has both positive and negative regulatory functions in the immune system. While vitamin A is required for normal formation of immune cells and epithelial cell barriers, vitamin A deficiency can lead to increased inflammatory responses and tissue damage. The mechanism with which vitamin A and its metabolites such as retinoids negatively regulate inflammatory responses has not been clearly defined. Recently, it has been established that retinoids promote the generation of immune-suppressive FoxP3(+) regulatory T cells while they suppress the T cell differentiation into inflammatory Th17 cells in the periphery such as intestine. These novel functions of retinoids provide a potentially important immune regulatory mechanism. In this review, we discuss the functions of retinoids in the development of the FoxP3(+) cells and Th17 cells, the phenotype and functions of retinoid-induced FoxP3(+) T cells, and the impact of retinoid-induced FoxP3(+) T cells on the immune tolerance.
引用
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页码:1 / 12
页数:12
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