Regulation of FoxP3+ regulatory T cells and Th17 cells by retinoids

被引:43
作者
Kim, Chang H. [1 ]
机构
[1] Purdue Univ, Purdue Canc Ctr, Dept Comparat Pathobiol, Lab Immunol & Hematopoiesis, W Lafayette, IN 47907 USA
来源
CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2008年
关键词
D O I
10.1155/2008/416910
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Vitamin A has both positive and negative regulatory functions in the immune system. While vitamin A is required for normal formation of immune cells and epithelial cell barriers, vitamin A deficiency can lead to increased inflammatory responses and tissue damage. The mechanism with which vitamin A and its metabolites such as retinoids negatively regulate inflammatory responses has not been clearly defined. Recently, it has been established that retinoids promote the generation of immune-suppressive FoxP3(+) regulatory T cells while they suppress the T cell differentiation into inflammatory Th17 cells in the periphery such as intestine. These novel functions of retinoids provide a potentially important immune regulatory mechanism. In this review, we discuss the functions of retinoids in the development of the FoxP3(+) cells and Th17 cells, the phenotype and functions of retinoid-induced FoxP3(+) T cells, and the impact of retinoid-induced FoxP3(+) T cells on the immune tolerance.
引用
收藏
页码:1 / 12
页数:12
相关论文
共 155 条
[91]   Oral tolerance in the absence of naturally occurring Tregs [J].
Mucida, D ;
Kutchukhidze, N ;
Erazo, A ;
Russo, M ;
Lafaille, JJ ;
de Lafaille, MAC .
JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (07) :1923-1933
[92]   Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid [J].
Mucida, Daniel ;
Park, Yunji ;
Kim, Gisen ;
Turovskaya, Olga ;
Scott, Iain ;
Kronenberg, Mitchell ;
Cheroutre, Hilde .
SCIENCE, 2007, 317 (5835) :256-260
[93]   Signaling and transcription in T helper development [J].
Murphy, KM ;
Ouyang, W ;
Farrar, JD ;
Yang, JF ;
Ranganath, S ;
Asnagli, H ;
Afkarian, M ;
Murphy, TL .
ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :451-494
[94]   Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells [J].
Nagalakshmi, ML ;
Rascle, A ;
Zurawski, S ;
Menon, S ;
Malefyt, RD .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2004, 4 (05) :679-691
[95]   Biochemical pathways of retinoid transport, metabolism, and signal transduction [J].
Napoli, JL .
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1996, 80 (03) :S52-S62
[96]   Retinoic acid biosynthesis and metabolism [J].
Napoli, JL .
FASEB JOURNAL, 1996, 10 (09) :993-1001
[97]   IL-6-gp130-STAT3 in T cells directs the development of IL-17+Th with a minimum effect on that of Treg in the steady state [J].
Nishihara, Mika ;
Ogura, Hideki ;
Ueda, Naoko ;
Tsuruoka, Mineko ;
Kitabayashi, Chika ;
Tsuji, Fumio ;
Aono, Hiroyuki ;
Ishihara, Katsuhiko ;
Huseby, Eric ;
Betz, Ulrich A. K. ;
Murakami, Masaaki ;
Hirano, Toshio .
INTERNATIONAL IMMUNOLOGY, 2007, 19 (06) :695-702
[98]   Essential autocrine regulation by IL-21 in the generation of inflammatory T cells [J].
Nurieva, Roza ;
Yang, Xuexian O. ;
Martinez, Gustavo ;
Zhang, Yongliang ;
Panopoulos, Athanasia D. ;
Ma, Li ;
Schluns, Kimberly ;
Tian, Qiang ;
Watowich, Stephanie S. ;
Jetten, Anton M. ;
Dong, Chen .
NATURE, 2007, 448 (7152) :480-U8
[99]   Retinoids in cancer chemoprevention [J].
Okuno, M ;
Kojima, S ;
Matsushima-Nishiwaki, R ;
Tsurumi, H ;
Muto, Y ;
Friedman, SL ;
Moriwaki, H .
CURRENT CANCER DRUG TARGETS, 2004, 4 (03) :285-298
[100]   Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells [J].
Pasare, C ;
Medzhitov, R .
SCIENCE, 2003, 299 (5609) :1033-1036