Activation of the ERK1/2 Mitogen-Activated Protein Kinase Cascade by Dentin Matrix Protein 1 Promotes Osteoblast Differentiation

被引：26

作者：

Eapen, Asha

Ramachandran, Amsaveni

Pratap, Jitesh ^{[2
]}

George, Anne ^{[1
]}

机构：

[1] Univ Illinois, Coll Dent MC 690, Brodie Tooth Dev Genet & Regenerat Med Res Lab, Chicago, IL 60607 USA

[2] Rush Univ, Med Ctr, Chicago, IL 60612 USA

来源：

CELLS TISSUES ORGANS | 2011年 / 194卷 / 2-4期

基金：

美国国家卫生研究院;

关键词：

Dentin matrix protein 1; ERK1/2 MAP kinase; Runx2; RGD; Osteoblast differentiation; SIGNALING PATHWAYS; EXPRESSION; DMP1; BIOMINERALIZATION; PROLIFERATION; CANCER; CELLS;

D O I：

10.1159/000324258

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

DMP1 has been shown to play many roles in osteogenesis. We recently demonstrated that calcium-mediated stress kinase activation by DMP1 leads to osteoblast differentiation. In this study we demonstrate that DMP1 can also activate the extracellular signal-regulated kinase (ERK)-MAPK pathway. This activation was mediated through the RGD integrin-binding domain in DMP1. Further, we demonstrate that Runx2, an essential transcription factor, is stimulated by the ERK-MAPK pathway. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：255 / 260

页数：6

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